Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy.

Related collections

Most cited references 118

Record: found
Abstract: found
Article: not found

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Hua Hu, Jian Gan, Peter Jonas (2014)

The success story of fast-spiking, parvalbumin-positive (PV(+)) GABAergic interneurons (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy. In 1995, the properties of these interneurons were completely unknown. Twenty years later, thanks to the massive use of subcellular patch-clamp techniques, simultaneous multiple-cell recording, optogenetics, in vivo measurements, and computational approaches, our knowledge about PV(+) interneurons became more extensive than for several types of pyramidal neurons. These findings have implications beyond the "small world" of basic research on GABAergic cells. For example, the results provide a first proof of principle that neuroscientists might be able to close the gaps between the molecular, cellular, network, and behavioral levels, representing one of the main challenges at the present time. Furthermore, the results may form the basis for PV(+) interneurons as therapeutic targets for brain disease in the future. However, much needs to be learned about the basic function of these interneurons before clinical neuroscientists will be able to use PV(+) interneurons for therapeutic purposes. Copyright © 2014, American Association for the Advancement of Science.

0 comments Cited 299 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

Nadine Gogolla, Jocelyn LeBlanc, Kathleen Quast … (2009)

One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of development. We examined whether Parvalbumin (PV)-positive inhibitory neurons, which normally drive experience-dependent circuit refinement (Hensch Nat Rev Neurosci 6:877–888, 1), are disrupted across heterogeneous ASD mouse models. We performed a meta-analysis of PV expression in previously published ASD mouse models and analyzed two additional models, reflecting an embryonic chemical insult (prenatal valproate, VPA) or single-gene mutation identified in human patients (Neuroligin-3, NL-3 R451C). PV-cells were reduced in the neocortex across multiple ASD mouse models. In striking contrast to controls, both VPA and NL-3 mouse models exhibited an asymmetric PV-cell reduction across hemispheres in parietal and occipital cortices (but not the underlying area CA1). ASD mouse models may share a PV-circuit disruption, providing new insight into circuit development and potential prevention by treatment of autism. Electronic supplementary material The online version of this article (doi:10.1007/s11689-009-9023-x) contains supplementary material, which is available to authorized users.

0 comments Cited 249 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells

Nathan W Gouwens, Staci A. Sorensen, Fahimeh Baftizadeh … (2020)

Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and reconstructed the local morphologies of 517 of those neurons. We find that most transcriptomic types (t-types) occupy specific laminar positions within visual cortex, and, for most types, the cells mapping to a t-type exhibit consistent electrophysiological and morphological properties. These properties display both discrete and continuous variation among t-types. Through multimodal integrated analysis, we define 28 met-types that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability. We identify layer-specific axon innervation pattern as a defining feature distinguishing different met-types. These met-types represent a unified definition of cortical GABAergic interneuron types, providing a systematic framework to capture existing knowledge and bridge future analyses across different modalities.

0 comments Cited 235 times – based on 0 reviews      Review now

All references

Author and article information

Contributors

Sabine Richard: URI : https://loop.frontiersin.org/people/32973Role: Role:

Juan Ren: URI : https://loop.frontiersin.org/people/2521504Role:

Frédéric Flamant: URI : https://loop.frontiersin.org/people/42211Role: Role:

Journal

Journal ID (nlm-ta): Front Endocrinol (Lausanne)

Journal ID (iso-abbrev): Front Endocrinol (Lausanne)

Journal ID (publisher-id): Front. Endocrinol.

Title: Frontiers in Endocrinology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1664-2392

Publication date (Electronic): 03 October 2023

Publication date Collection: 2023

Volume: 14

Electronic Location Identifier: 1256877

Affiliations

[1] Institut de Génomique Fonctionnelle de Lyon, UMR5242, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard-Lyon 1, USC1370 Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement , Lyon, France

Author notes

Edited by: Laurent M. Sachs, Muséum National d’Histoire Naturelle, France

Reviewed by: Heike Heuer, Essen University Hospital, Germany; Mary E. Gilbert, United States Environmental Protection Agency (EPA), United States

*Correspondence: Frédéric Flamant, Frederic.flamant@ 123456ens-lyon.fr

Article

DOI: 10.3389/fendo.2023.1256877

PMC ID: 10579935

PubMed ID: 37854197

SO-VID: 497a39fd-1189-485e-98e4-3985e0ff70e8

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 11 July 2023

Date accepted : 18 September 2023

Page count

Figures: 0, Tables: 1, Equations: 0, References: 119, Pages: 13, Words: 8377

Funding

JR was supported by grants of the China Scholarship Council and ENS de Lyon, within the framework of the PROSFER program (Program of Sino-French Education for Research). Research in our group is funded by the European Union’s Horizon 2020 research and innovation program, under grant agreement no. 825753 (ERGO) and by the French Agence Nationale de la Recherche (Hypothyro project, ANR 22-CE14-0026-01).

Custom metadata

section-in-acceptance Thyroid Endocrinology

ScienceOpen disciplines: Endocrinology & Diabetes

Keywords: brain development,parvalbumin interneurons,thyroid hormone receptors,animal models,hypothyroidism,neurological disorders

Data availability:

ScienceOpen disciplines: Endocrinology & Diabetes

Keywords: brain development, parvalbumin interneurons, thyroid hormone receptors, animal models, hypothyroidism, neurological disorders

Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms

Read this article at

Abstract

Related collections

Bioscientifica Open Endocrinology