Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

A brain-specific microRNA regulates dendritic spine development.

Nature

metabolism, Animals, Synapses, Rats, genetics, RNA, Messenger, biosynthesis, Protein Kinases, Protein Biosynthesis, Organ Specificity, MicroRNAs, Lim Kinases, cytology, Hippocampus, Gene Expression Regulation, Developmental, Dendritic Spines, Cell Shape, pharmacology, Brain-Derived Neurotrophic Factor, Brain, Base Sequence

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of microRNAs have been isolated from the mammalian brain, neither the specific microRNAs that regulate synapse function nor their target mRNAs have been identified. Here we show that a brain-specific microRNA, miR-134, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines--postsynaptic sites of excitatory synaptic transmission. This effect is mediated by miR-134 inhibition of the translation of an mRNA encoding a protein kinase, Limk1, that controls spine development. Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity.

      Related collections

      Author and article information

      Journal
      10.1038/nature04367
      16421561

      Comments

      Comment on this article