Objective To examine the relationship between clustering of metabolic abnormalities with non-alcoholic fatty liver disease (NAFLD) in hypertensive children and adolescents, and to provide a scientific reference for the prevention and control of NAFLD among children and adolescents.
Methods Data were based on a school-based cross-sectional study conducted from September 2012 to September 2014 in Jinan. A total of 261 hypertensive children and adolescents aged 6 to 17 years were included in this study. Chi-square test was used to analyze the prevalence of NAFLD by numbers of metabolic abnormalities. Multivariable logistic regression model was used to examine the relationship between clustering of metabolic abnormalities and NAFLD in hypertensive children and adolescents after adjustment for potential confounding variables.
Results Among the included 261 hypertensive participants, the prevalence of NAFLD with the number of metabolic abnormalities ≤1, 2 and ≥3 was 5.3%, 25. 5% and 36.0%, respectively. After adjustment for sex, age and systolic/diastolic blood pressure, compared with hypertensive children and adolescents carrying ≤1 metabolic disorder, those with two metabolic disorders had 6.51 (95% CI = 2.52–16.81) times higher risk for NAFLD, and those with ≥3 metabolic disorders had 8.89 (95% CI = 3.03–26.06) times higher risk.
Conclusion Clustering of metabolic abnormalities is an independent risk factor for NAFLD in hypertensive youth. Comprehensive prevention and control of metabolic disorders in childhood may be helpful to prevent NAFLD.
【摘要】 目的 探讨代谢异常指标聚集性与髙血压儿童青少年非酒精性脂肪肝 (NAFLD) 之间的关系, 为儿童青少年 NAFLD的预防和控制提供科学依据。 方法 数据来源于 2012 年 9 月一2014 年 9 月开展的以学校为基础的横断面研究, 共纳人济南市 261 名 6~ 17 岁髙血压中小学生。采用趋势; χ 2 检验分析 NAFLD 检出率随代谢异常数量增加的变化趋势; 控 制潜在的混杂变量后, 采用多元Logistic回归模型分析髙血压儿童青少年代谢异常聚集性对 NAFLD 的影响。 结果 在髙 血压儿童青少年中, 携带 ≤1, 2, ≥3 个代谢异常指标的NAFLD检出率分别为 5.3 %, 25.5% 和 36.0%。控制性别、年龄和血 压等因素后, 携带 2 和≥3个代谢异常指标组罹患NAFLD的风险是携带 ≤1 个代谢异常指标组的6.51 (95% CI =2.52 ~ 16.81) 和 8.89 倍 (95% CI = 3.03~26.06)。 结论 代谢异常指标聚集性可能会增加髙血压儿童青少年NAFLD的罹患风险。 综合防控各种代谢指标的异常, 可能有助于预防和控制髙血压儿童青少年的 NAFLD。