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      Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation

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          Abstract

          New England Journal of Medicine, 331(14), 889-895

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          Most cited references19

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          The etiology of chondromalacia patellae.

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            The resurfacing of adult rabbit articular cartilage by multiple perforations through the subchondral bone.

            The repair of articular cartilage removed from the femora of adult rabbits at the knee was studied. When multiple perforations were made through the subchondral bone a cartilaginous material, staining heavily with safranin O, first filled the holes. This material resembled hyaline cartilage, and by twelve months there was complete resurfacing of the joint, although the material lost its hyaline appearance after eight months and at one year it resembled dense collagenous tissue.
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              The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee.

              The strength of the associations of knee injury and obesity with osteoarthritis of the knee was studied for 3,885 adults aged 45-74 years who received knee x-rays in the First National Health and Nutrition Examination Survey, 1971-1975. Bilateral osteoarthritis was more prevalent (5%) than unilateral osteoarthritis (2%). Bilateral osteoarthritis was twice as prevalent in women as in men; however, there was no sex difference in the prevalence of unilateral osteoarthritis. Odds ratios calculated by means of polychotomous logistic regression indicated that obesity, knee injury, and age were significantly associated with both unilateral and bilateral knee osteoarthritis. Obesity was a stronger predictor of bilateral osteoarthritis than was knee injury (odds ratio (OR) = 6.6 for obesity, 3.5 for right knee injury, and 3.0 for left knee injury; 95% confidence interval (CI) 4.71-9.18, 1.80-6.83, and 1.51-6.11, respectively). Knee injury was a stronger predictor of unilateral osteoarthritis than was obesity (OR = 3.4 and 2.4 for obesity in the right and left knee, respectively (95% CI 1.55-7.29 and 0.96-5.75) and OR = 16.3 and 10.9 for injury in the right and left knee, respectively (95% CI 6.50-40.89 and 3.72-31.93]. These findings suggest that different pathogenetic processes may exist for unilateral and bilateral knee osteoarthritis.
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                Author and article information

                Journal
                Massachusetts Medical Society
                1994
                06 October 1994
                16 December 2017
                Article
                10.1056/NEJM199410063311401
                8078550
                49beccb0-9e29-4129-902c-94379b6d28d6
                History

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