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      Renal Effects of Essential Fatty Acid Deficiency in Hydropenic and Volume-Expanded Rats

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          The aim of this paper was to study the effects of essential fatty acid (EFA) on fractional sodium excretion (FE<sub>Na<sup>+</sup></sub>) and renal hemodynamics in rats during hydropenia (H) and acute volume expansion (VE), successively. Mean arterial pressure (MAP) and renal blood flow (RBF) were measured using a blood pressure transducer and a flow probe, respectively, both connected to a flowmeter. Glomerular filtration rate (GFR) was estimated by inulin clearance. The rats receiving coconut oil as only source of dietary lipids (the EFA-deficient group) presented lower levels of linoleic acid in cortex and medulla and lower body weight than the rats receiving soy oil in place of coconut oil (the control non-EFA-deficient group). During H, the EFA-deficient rats exhibited a lower level of renal vascular resistance resulting in a higher level of RBF and a higher urinary flow (V’) and FE<sub>Na<sup>+</sup></sub>, although GFR was lower than in the control group. During VE, the rats of the control group responded with increased MAP, RBF, V’ and FE<sub>Na<sup>+</sup></sub>, which were not found in the EFA-deficient group, suggesting an impaired hemodynamic adjustment in EFA deficiency. In conclusion, both experimental conditions revealed that EFA deficiency affects the renal hemodynamics.

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          Author and article information

          Kidney Blood Press Res
          Kidney and Blood Pressure Research
          S. Karger AG
          06 February 2002
          : 25
          : 1
          : 27-33
          aDepartment of Physiology and Pharmacology, Biological Science Center, Federal University of Pernambuco, Recife, PE, Brazil; bLaboratoire de Nutrition Humaine et Athérogénèse, Université de Montpellier I, Montpellier, France
          49432 Kidney Blood Press Res 2002;25:27–33
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 1, Tables: 3, References: 33, Pages: 7
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