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      Renal Effects of Essential Fatty Acid Deficiency in Hydropenic and Volume-Expanded Rats

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          Abstract

          The aim of this paper was to study the effects of essential fatty acid (EFA) on fractional sodium excretion (FE<sub>Na<sup>+</sup></sub>) and renal hemodynamics in rats during hydropenia (H) and acute volume expansion (VE), successively. Mean arterial pressure (MAP) and renal blood flow (RBF) were measured using a blood pressure transducer and a flow probe, respectively, both connected to a flowmeter. Glomerular filtration rate (GFR) was estimated by inulin clearance. The rats receiving coconut oil as only source of dietary lipids (the EFA-deficient group) presented lower levels of linoleic acid in cortex and medulla and lower body weight than the rats receiving soy oil in place of coconut oil (the control non-EFA-deficient group). During H, the EFA-deficient rats exhibited a lower level of renal vascular resistance resulting in a higher level of RBF and a higher urinary flow (V’) and FE<sub>Na<sup>+</sup></sub>, although GFR was lower than in the control group. During VE, the rats of the control group responded with increased MAP, RBF, V’ and FE<sub>Na<sup>+</sup></sub>, which were not found in the EFA-deficient group, suggesting an impaired hemodynamic adjustment in EFA deficiency. In conclusion, both experimental conditions revealed that EFA deficiency affects the renal hemodynamics.

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          Author and article information

          Journal
          KBR
          Kidney Blood Press Res
          10.1159/issn.1420-4096
          Kidney and Blood Pressure Research
          S. Karger AG
          1420-4096
          1423-0143
          2002
          2002
          06 February 2002
          : 25
          : 1
          : 27-33
          Affiliations
          aDepartment of Physiology and Pharmacology, Biological Science Center, Federal University of Pernambuco, Recife, PE, Brazil; bLaboratoire de Nutrition Humaine et Athérogénèse, Université de Montpellier I, Montpellier, France
          Article
          49432 Kidney Blood Press Res 2002;25:27–33
          10.1159/000049432
          11834874
          © 2002 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 1, Tables: 3, References: 33, Pages: 7
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/49432
          Categories
          Original Paper

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