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      Localization of function within the dorsal hippocampus: the role of the CA3 subregion in paired-associate learning.

      Behavioral Neuroscience
      Animals, Association Learning, physiology, Brain Mapping, Dentate Gyrus, Environment, Hippocampus, pathology, Male, Odors, Rats, Rats, Long-Evans

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          Abstract

          Computational models and electrophysiological data suggest that the CA3 subregion of the hippocampus supports the formation of arbitrary associations; however, no behavioral studies have been conducted to test this hypothesis. Rats with neurotoxin-induced lesions of dorsal dentate gyrus (DG), CA3, or CA1 were tested on object-place and odor-place paired-associate tasks to test whether the mechanism that supports paired-associate learning is localized to the CA3 subregion of the dorsal hippocampus or whether all hippocampal subregions contribute to paired-associate learning. The data indicate that rats with DG or CA1 lesions learned the tasks as well as controls; however, CA3-lesioned rats were impaired in learning the tasks. Thus, the CA3 subregion of the dorsal hippocampus contains a mechanism to support paired-associate learning. (c) 2003 APA

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          Journal
          14674856
          10.1037/0735-7044.117.6.1385

          Chemistry
          Animals,Association Learning,physiology,Brain Mapping,Dentate Gyrus,Environment,Hippocampus,pathology,Male,Odors,Rats,Rats, Long-Evans

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