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      The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.

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          Abstract

          Cachexia is a common complication of cancer and may be responsible for 22% of all cancer-related deaths. The exact cause of death in cancer cachexia patients is unknown. Recently, atrophy of the heart has been described in cancer cachexia animal models, which resulted in impaired cardiac function and is likely to contribute to mortality. In cancer patients hyperuricaemia independent of tumour lysis syndrome is often associated with a worse prognosis. Xanthine oxidase (XO) metabolizes purines to uric acid and its inhibition has been shown to improve clinical outcome in patients with chronic heart failure.

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          Author and article information

          Journal
          Int. J. Cardiol.
          International journal of cardiology
          1874-1754
          0167-5273
          Oct 9 2013
          : 168
          : 4
          Affiliations
          [1 ] Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany; Center for Cardiovascular Research, Charite Medical School, Berlin, Germany; Norwich Medical School, University of East Anglia, Norwich, UK. Electronic address: jochen.springer@charite.de.
          Article
          S0167-5273(13)00991-1
          10.1016/j.ijcard.2013.05.063
          23751350
          49d40d61-7355-4f87-b7ad-928fbf6afe4c
          Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
          History

          Cancer cachexia,Cardiac function,Heart,Oxypurinol,Uric acid,Xanthine oxidase

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