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      Temperature-Controlled High Frequency Ablation for Creation of Transmyocardial Channels: In vivo Validation of a Novel Method

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          Objective: We investigated the feasibility and short-term effects of a novel procedure to create intramyocardial channels by means of high frequency (HF) ablation in a rabbit in vivo model. Methods: A flexible catheter ending in a cylindrical electrode (diameter 0.7 mm) with a sharpened tip was used for HF energy application following transmyocardial insertion. Power-controlled or energy-controlled energy applications were performed in 16 anesthetized rabbits after thoracotomy with a follow-up for 3 h. Assessment of myocardial channels and the necrotic zone was performed by morphometric quantification in serial sections. The ferret diameter was used to compare channel dimensions and the extent of necrosis. Results: Thirty-nine power-controlled and 54 temperature-controlled HF applications were performed. The shape of identified channels was round in 71% and 69% had a lumen patency of ≥2/3 of the channel. Ferret diameter of the channels was 414 ± 180 μm and of the necrotic zone 3,558 ± 1,200 μm. In temperature-controlled applications, channel dimensions were strongly influenced by the maximum tissue temperature and the duration of energy delivery (T<sub>max</sub>: p = 0.0006; duration: p = 0.003). Channel and necrosis dimensions correlated better with biometric parameters in temperature-controlled compared with power-controlled applications. Conclusion: Mechanically created transmyocardial channels can be stabilized by HF heating of the surrounding tissue. A high percentage of these channels remain patent. The channel dimensions are closely correlated with maximum temperature and duration of energy delivery in a temperature-controlled application mode.

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          Histologic appearance of transmyocardial laser channels after 4 1/2 weeks.

          Preliminary results of clinical studies suggest that transmyocardial laser revascularization is an effective treatment for patients with chronic angina that cannot be treated by other means. The mechanism of this effect remains controversial. We present autopsy results from a patient obtained 4 1/2 weeks after operation that show that the channels do not maintain patency. Further work is needed to determine the frequency of channel patency and its relation to clinical benefit.
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            Physiology, histology, and 2-week morphology of acute transmyocardial channels made with a CO2 laser

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              End stage coronary disease treated with the transmyocardial CO2 laser revascularisation: a chance for the 'inoperable' patient


                Author and article information

                S. Karger AG
                September 2000
                02 October 2000
                : 93
                : 4
                : 234-241
                aMedical Clinic II, bInstitute of Pathology and cInstitute for Medical Statistics and Documentation, University Hospital, Mainz, Germany; dMedtronic, Bakken Research Center, Maastricht, The Netherlands
                7032 Cardiology 2000;93:234–241
                © 2000 S. Karger AG, Basel

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                Page count
                Figures: 6, References: 16, Pages: 8
                General Cardiology – Basic Science


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