7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Neighborhoods encompass complex environments comprised of unique economic, physical, and social characteristics that have a profound impact on the residing individual’s health and, collectively, on the community’s wellbeing. Neighborhood disadvantage (ND) is one of several factors that prominently contributes to racial breast cancer (BC) health disparities in American women. African American (AA) women develop more aggressive breast cancer features, such as triple-negative receptor status and more advanced histologic grade and tumor stage, and suffer worse clinical outcomes than European American (EA) women. While the adverse effects of neighborhood disadvantage on health, including increased risk of cancer and decreased longevity, have recently come into focus, the specific molecular mechanisms by which neighborhood disadvantage increase BC risk and worsen BC outcomes (survivorship, recurrence, mortality) are not fully elucidated. This review illuminates the probable biological links between neighborhood disadvantage and predominantly BC risk, with an emphasis on stress reactivity and inflammation, epigenetics and telomere length in response to adverse neighborhood conditions.

          Related collections

          Author and article information

          Journal
          9100846
          1173
          Cancer Causes Control
          Cancer Causes Control
          Cancer causes & control : CCC
          0957-5243
          1573-7225
          29 May 2019
          20 May 2019
          July 2019
          01 July 2020
          : 30
          : 7
          : 677-686
          Affiliations
          [1 ]Department of Biology, Georgia State University, Atlanta, GA 30303
          [2 ]Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322
          [3 ]Department of Radiation Oncology, Glenn Family Breast Center, Winship Cancer Institute, Emory University, Atlanta, GA 30322
          Author notes
          Corresponding Author: Ritu Aneja, Department of Biology, Georgia State University, Atlanta, GA 30303 raneja@ 123456gsu.edu ; Phone: 404-413-5417; Fax: 404-413-5301
          Article
          PMC7043809 PMC7043809 7043809 nihpa1529883
          10.1007/s10552-019-01180-4
          7043809
          31111277
          49dd7299-bbf1-4be0-8f5c-63ffdf2cad80
          History
          Categories
          Article

          triple-negative breast cancer,inflammation,Neighborhood disadvantage,telomere length,epigenetics,racial disparities

          Comments

          Comment on this article