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      Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)

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          Abstract

          In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

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          Journal
          12869766
          10.1126/science.1083968

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