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Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium.
Mitsuki Kubo
1 ,
Kensuke Egashira ,
Takahiro Inoue ,
Jun-ichiro Koga ,
Shinichiro Oda ,
Ling Chen ,
Kaku Nakano ,
Tetsuya Matoba ,
Yoshiaki Kawashima ,
Kaori Hara ,
Hiroyuki Tsujimoto ,
Katsuo Sueishi ,
Ryuji Tominaga ,
Kenji Sunagawa
Jun 2009
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Abstract
Recent clinical studies of therapeutic neovascularization using angiogenic growth factors demonstrated smaller therapeutic effects than those reported in animal experiments. We hypothesized that nanoparticle (NP)-mediated cell-selective delivery of statins to vascular endothelium would more effectively and integratively induce therapeutic neovascularization.