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All four possible trihalomethanes (THMs) containing bromine and chlorine, as well
as perchloroethylene (PCE), were evaluated for their ability to produce DNA strand
breaks, alpha 2u-globulin rich renal deposits, and testosterone changes in male F-344
rats. Rats received daily equimolar doses (0.75 or 1.5 mmol/kg) of THMs or PCE (1000
mg/kg) in 4% Emulphor vehicle by oral gavage for 7 days. No significant DNA strand
breaks were produced by any THM or PCE treatment. PCE treatment produced increased
hyaline droplet formation in renal tubules. However, all THM treatments reduced or
eliminated the appearance of renal hyaline droplets. All four THM treatments also
produced a decrease in serum testosterone concentrations on day 7, which might account
for decreased hyaline droplet formation. No significant increase in cell proliferation,
measured by [3H]thymidine incorporation in vivo, appeared in this 1-week study.