Thalidomide for steroid-dependent chronic disseminated candidiasis after stem cell transplantation: A case report.

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Abstract

Chronic disseminated candidiasis (CDC) is a rare and difficult-to-treat invasive fungal disease occurring mainly after prolonged and profound neutropenia. We describe the case of a 59-year-old man successfully treated with thalidomide for CDC recurrences after an autologous transplantation. We add evidence of the effectiveness of immunomodulatory drugs to manage inflammatory reconstitution immune syndrome-related refractory CDC.

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Journal

Journal ID (iso-abbrev): Transpl Infect Dis

Title: Transplant infectious disease : an official journal of the Transplantation Society

Publisher: Wiley

ISSN (Electronic): 1399-3062

ISSN (Print): 1398-2273

Publication date (Electronic): Feb 2017

Volume: 19

Issue: 1

Affiliations

[1 ] Hôpital Necker-Enfants Malades, Centre d'Infectiologie Necker Pasteur, APHP, Sorbonne Paris Cité, Institut Hospitalo-Universitaire Imagine, Paris, France.

[2 ] Hôpital Necker-Enfants Malades, Immunologie Biologique, APHP, Paris, France.

[3 ] PRES Sorbonne-Paris-Cité, Université Paris Descartes, Paris, France.

[4 ] Hôpital Européen Georges Pompidou, Service de Médecine Nucléaire, APHP, Paris, France.

[5 ] Hôpital Necker-Enfants Malades, Laboratoire de Microbiologie, Unité de Mycologie-Parasitologie, APHP, Paris, France.

[6 ] Institut Pasteur, Unité d'histopathologie Humaine et Modèles Animaux, Paris, France.

[7 ] Hôpital Avicenne, Service d'hématologie, APHP, Bobigny, France.

[8 ] Hôpital Necker-Enfants Malades, Service de Radiologie Adulte, APHP, Paris, France.

[9 ] Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France.

[10 ] CNRS, URA 3012, Paris, France.

Article

DOI: 10.1111/tid.12637

PubMed ID: 27862711

SO-VID: 49f57653-574c-4cbf-87e7-1eb8787a125b

History

Keywords: Candida ,chronic disseminated candidiasis,immune reconstitution inflammatory syndrome,stem cell transplantation

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Keywords: Candida , chronic disseminated candidiasis, immune reconstitution inflammatory syndrome, stem cell transplantation

Thalidomide for steroid-dependent chronic disseminated candidiasis after stem cell transplantation: A case report.

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