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      Lung cancer risk in painters: a meta-analysis Translated title: Risco de câncer de pulmão em pintores: uma meta-análise

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          Abstract

          We conducted a meta-analysis to quantitatively compare the association between occupation as a painter and the incidence or mortality from lung cancer. PubMed and the reference lists of pertinent publications were searched and reviewed. For the meta-analysis, we used data from 47 independent cohort, record linkage, and case-control studies (from a total of 74 reports), including > 11,000 incident cases or deaths from lung cancer among painters. Three authors independently abstracted data and assessed study quality. The summary relative risk (meta-RR, random effects) for lung cancer in paint-ers was 1.35 [95% confidence interval (CI), 1.29-1.41; 47 studies] and 1.35 (95% CI, 1.21-1.51; 27 studies) after controlling for smoking. The relative risk was higher in never-smokers (meta-RR = 2.00; 95% CI, 1.09-3.67; 3studies) and persisted when restricted to studies that adjusted for other occupational exposures (meta-RR = 1.57; 95% CI, 1.21-2.04; 5 studies). These results support the conclusion that occupational exposures in painters are causally associated with the risk of lung cancer.

          Translated abstract

          Conduziu-se uma meta-análise para comparar quatitativamente a associação entre o trabalho de pintor e a incidência ou mortalidade por câncer de pulmão. PubMed e listas de referência de publicações pertinentes foram pesquisadas e revisadas. Para a análise, foram usados dados de 47 estudos de caso, coorte independente e ligação de dados (de um total de 74 relatórios), incluindo > 11 mil casos de incidentes ou morte por câncer de pulmão entre pintores. Três autores coletaram dados e avaliaram a qualidade de estudo. O risco relativo (meta-RR, efeitos aleatórios) de câncer de pulmão em pintores foi de 1,35 [95% intervalo de confiança (IC), 1,29-1,41; 47 estudos] e 1,35 (95% IC, 1,21-1,51; 27 estudos) depois de se destacar os fumantes. O risco relativo foi maior naqueles que nunca fumaram (meta-RR = 2.00; 95% CI, 1,09-3,67; 3 estudos) e persistiu quanto restringido a estudos que foram ajustados para outras exposições ocupacionais (meta-RR = 1,57; 95% CI, 1,21-2,04; 5 estudos). Estes resultados sustentam a conclusão de que exposições ocupacionais em pintores são causadamente associada com o risco de câncer de pulmão.

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          Meta-analysis in clinical trials.

          This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to include relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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            Modern epidemiology

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              Modern Epidemiology

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                Author and article information

                Journal
                csc
                Ciência & Saúde Coletiva
                Ciênc. saúde coletiva
                ABRASCO - Associação Brasileira de Saúde Coletiva (Rio de Janeiro, RJ, Brazil )
                1413-8123
                1678-4561
                August 2011
                : 16
                : 8
                : 3613-3632
                Affiliations
                [02] Atlanta orgnameEmory University orgdiv1Rollins School of Public Health orgdiv2Department of Environmental and Occupational Health United States
                [01] Turin orgnameUniversità di Torino orgdiv1Department of Biomedical Sciences and Human Oncology Italy
                Article
                S1413-81232011000900029 S1413-8123(11)01600829
                10.1590/S1413-81232011000900029
                4a0dde86-a143-4b87-b584-ef6ee0b75d21

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 31 August 2009
                : 22 October 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 87, Pages: 20
                Product

                SciELO Public Health

                Self URI: Full text available only in PDF format (EN)
                Categories
                Review

                Metaanalysis,Epidemiologia,Lung cancer,Câncer de pulmão,Meta-análise,Pintor,Epidemiology,Painter

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