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      Fast adaptive optics scanning light ophthalmoscope retinal montaging

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          Abstract

          The field of view of high-resolution ophthalmoscopes that require the use of adaptive optics (AO) wavefront correction is limited by the isoplanatic patch of the eye, which varies across individual eyes and with the portion of the pupil used for illumination and/or imaging. Therefore all current AO ophthalmoscopes have small fields of view comparable to, or smaller than, the isoplanatic patch, and the resulting images have to be stitched off-line to create larger montages. These montages are currently assembled either manually, by expert human graders, or automatically, often requiring several hours per montage. This arguably limits the applicability of AO ophthalmoscopy to studies with small cohorts and moreover, prevents the ability to review a real-time captured montage of all locations during image acquisition to further direct targeted imaging. In this work, we propose stitching the images with our novel algorithm, which uses oriented fast rotated brief (ORB) descriptors, local sensitivity hashing, and by searching for a ‘good enough’ transformation, rather than the best possible, to achieve processing times of 1–2 minutes per montage of 250 images. Moreover, the proposed method produces montages which are as accurate as previous methods, when considering the image similarity metrics: normalised mutual information (NMI), and normalised cross correlation (NCC).

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          A Combined Corner and Edge Detector

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            ORB: An efficient alternative to SIFT or SURF

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              Machine Learning for High-Speed Corner Detection

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                Author and article information

                Journal
                Biomed Opt Express
                Biomed Opt Express
                BOE
                Biomedical Optics Express
                Optical Society of America
                2156-7085
                15 August 2018
                01 September 2018
                15 August 2018
                : 9
                : 9
                : 4317-4328
                Affiliations
                [1 ]Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK
                [2 ]Translational Imaging Group, Centre for Medical Image Computing, University College London, London, UK
                [3 ]NIHR Biomedical Research Centre at Moorfields Eye Hospital and Institute of Ophthalmology, University College London, London, UK
                [4 ]Medical College of Wisconsin, WI, USA
                [5 ]Stanford University, CA, USA
                Author notes
                Article
                332844
                10.1364/BOE.9.004317
                6157757
                30615701
                4a2125af-fa99-4cb7-a270-2b9a8a07ec01
                Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

                Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

                History
                : 29 May 2018
                : 14 July 2018
                : 15 July 2018
                Funding
                Funded by: Engineering and Physical Sciences Research Council (EPSRC) 10.13039/501100000266
                Award ID: 099173/Z/12/
                Award ID: 203145Z/16/Z
                Award ID: EP/L016478/1
                Funded by: H2020 European Research Council (ERC) 10.13039/100010663
                Award ID: 714562
                Funded by: Moorfields Eye Charity
                Award ID: R180004A
                Funded by: National Institute for Health Research (NIHR) 10.13039/501100000272
                Funded by: National Institutes of Health (NIH) 10.13039/100000002
                Award ID: P30 EY001931
                Award ID: R01 EY017607
                Award ID: R01 EY025231
                Award ID: U01 EY025477
                Funded by: Research to Prevent Blindness (RPB) 10.13039/100001818
                Funded by: Wellcome Trust 10.13039/100010269
                Categories
                Article

                Vision sciences
                Vision sciences

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