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      Asymmetric organocatalytic domino reactions.

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          Abstract

          The current status of organic synthesis is hampered by costly protecting-group strategies and lengthy purification procedures after each synthetic step. To circumvent these problems, the synthetic potential of multicomponent domino reactions has been utilized for the efficient and stereoselective construction of complex molecules from simple precursors in a single process. In particular, domino reactions mediated by organocatalysts are in a way biomimetic, as this principle is used very efficiently in the biosynthesis of complex natural products starting from simple precursors. In this Minireview, we discuss the current development of this fast-growing field.

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          Author and article information

          Journal
          Angew Chem Int Ed Engl
          Angewandte Chemie (International ed. in English)
          Wiley
          1433-7851
          1433-7851
          2007
          : 46
          : 10
          Affiliations
          [1 ] Institut für Organische Chemie, RWTH Aachen, Landoltweg 1, 52074 Aachen, Germany. enders@rwth-aachen.de
          Article
          10.1002/anie.200603129
          17225236
          4a41cda7-668e-4efa-979e-57cd64762d1f
          History

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