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      Fast Tracks and Roadblocks for Zika Vaccines

      review-article
      Author(s): 1 , 1 , 2 , 1 , *
      Publication date (Electronic):
      Journal: Vaccines
      Publisher: MDPI
      Keywords: Zika virus, vaccine, immune responses, delivery systems

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          Abstract

          In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into clinical trials. Nonetheless, the need for a vaccine is crucial in order to eradicate this re-emerging arthropod-borne virus which remained silent since its first discovery in 1947. In this review, we focused on how the inconspicuous virus managed to spread, the key immunological factors required for a vaccine and the various vaccine platforms that are currently being studied.

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          Most cited references60

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          Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease.

          Sri Hadinegoro, José Arredondo-García, Maria Capeding … (2015)
          A candidate tetravalent dengue vaccine is being assessed in three clinical trials involving more than 35,000 children between the ages of 2 and 16 years in Asian-Pacific and Latin American countries. We report the results of long-term follow-up interim analyses and integrated efficacy analyses.
          Article 0 comments Cited 410 times – based on 0 reviews     Review now
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            Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria.

            F.N MacNamara (1954)
            Article 0 comments Cited 264 times – based on 0 reviews     Review now
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              Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys.

              P Abbink, R. A. Larocca, R. A. De La Barrera … (2016)
              Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans.
              Article 0 comments Cited 242 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Vaccines (Basel)
                Journal ID (iso-abbrev): Vaccines (Basel)
                Journal ID (publisher-id): vaccines
                Title: Vaccines
                Publisher: MDPI
                ISSN (Electronic): 2076-393X
                Publication date (Electronic): 21 November 2018
                Publication date Collection: December 2018
                Volume: 6
                Issue: 4
                Electronic Location Identifier: 77
                Affiliations
                [1 ]Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore; khairunnisa_ghaffar@ 123456immunol.a-star.edu.sg (K.A.G.); lisa_ng@ 123456immunol.a-star.edu.sg (L.F.P.N.)
                [2 ]Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, UK
                Author notes
                [* ]Correspondence: renia_laurent@ 123456immunol.a-star.edu.sg ; Tel.: +65-6407-0005
                Author information
                https://orcid.org/0000-0003-0349-1557
                Article
                Publisher ID: vaccines-06-00077
                DOI: 10.3390/vaccines6040077
                PMC ID: 6313897
                PubMed ID: 30469444
                SO-VID: 4a4482df-2a5d-4377-be1f-aafe47d78583
                Copyright © © 2018 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 28 October 2018
                Date accepted : 20 November 2018
                Categories
                Subject: Review

                Keywords: zika virus,vaccine,immune responses,delivery systems
                Data availability:
                Keywords: zika virus, vaccine, immune responses, delivery systems

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