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      Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

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          Abstract

          Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          October 31 2019
          November 01 2019
          October 31 2019
          November 01 2019
          : 366
          : 6465
          : 628-631
          Article
          10.1126/science.aax5440
          7309589
          31672896
          4a50c1e1-1f5e-463b-9acd-786bf9840027
          © 2019

          http://www.sciencemag.org/about/science-licenses-journal-article-reuse

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