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      Making guidelines, research and scientific papers as simple as possible

      editorial
      The European Journal of General Practice
      Taylor & Francis

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          Abstract

          Life is really simple, but we insist on making it complicated [1]. —Confucius We live in a world in which we are constantly busy, and there are seemingly endless numbers of options for everything [2]. At each turn, life seems to present numerous complications. It becomes hard to resist the allure of doing more things and trying to solve a myriad of problems. We believe that life is much more complicated than it really is. Conventional wisdom tells us that greater choice is for the greater good, but is this correct? Primary care can benefit the population by improving overall long-term patient care and health with preventive and educational measures, appropriate and focused provision of care, and evidence-based management of acute and chronic physical, mental and social health issues. This means that primary care involves the broadest scope of healthcare. Consequently, a general practitioner (GP) must possess a wide breadth of knowledge in many areas. Not everyone knows or even needs to know the details of all the medical conditions we are handling. Also, not everyone can afford the time or have sufficient skills to be able to cope with lengthy medical rigmarole. In the same way that we often, consciously or unconsciously, covet a more straightforward approach to life, we unintentionally try to embrace simplicity as primary care professionals. This principle, also called parsimony, is the idea that simpler explanations of observations are preferred to those that are more convoluted—conventionally referred to as Occam’s razor. As GPs we are obliged to reduce unnecessary and inappropriate medical care, following the ‘Less is More’ policy and make things as simple as we can. We must communicate with our patients simply and straightforwardly. The acronym KISS or ‘Keep it simple, stupid’ is a valuable piece of advice when communicating with patients. No matter how complicated the situation is, we must try to ask ourselves, ‘Is this as fair, clear, reliable and to the point as required?’ Guidelines are meant to simplify the management of diseases and increase GP adherence [3]. Recent years have seen the development of a wide array of evidence-based guidelines for clinical practice. High-quality healthcare has various spheres but its essence is the need to ensure that care is effective. It is, therefore, important that patients receive the most convenient care every time that they are treated. Studies indicate a clear association between lack of adherence and worse clinical outcomes. For example, lack of adherence to guidelines has found to increase hospital admissions, mortality rate, quality of life and loss of productivity in patients with chronic obstructive pulmonary disease (COPD) [4]. Common themes arising in qualitative studies on lack of GP adherence to guidelines are that complexity makes it difficult to follow or clinicians feel it is not relevant to their situation. Strategies to improve guideline usage tend to focus on dissemination and education. These approaches, however, do not address some of the more complex individual and systemic factors that influence whether a guideline is used or not in clinical practice. To consider approaches to improving GP adherence to guidelines, understanding barriers to guideline adherence is essential. Despite many clear and straightforward guidelines, an increasing number are hard to follow, confusing, and sometimes lack agreement. Consider, for example, the different guidelines available for such common conditions as the requirement for anticoagulation, management of sore throat or treatment of COPD. Grol et al. found that the implementation of guidelines that were precisely and clearly defined by clinicians was much higher compared with vague and non-specific guidelines (67% vs 36% of the occasions, respectively) [5]. Not only GPs prefer simpler guidelines. Michie et al. carried out a clinical trial in which mental health service users received either the original text of the NICE public guidelines for the management of schizophrenia or a behaviourally specified text with the same content, but in a simpler format [6]. The latter led to stronger intentions to implement the guidelines, more positive attitudes towards them, and greater perceived behavioural control overusing them. As Schwartz argues in his 2004 book The Paradox of Choice, providing infinite choice is paralyzing and exhausts the human psyche [7]. Similarly, a complicated guideline or algorithm with multiple choices can be frustrating. Guidelines must assist physicians with the best treatment in a given situation and avoid considering numerous possibilities, especially when guidelines for the same condition are different. Too much choice undermines happiness; too many guidelines, which are not always homogeneous, undermine confidence and adherence. Simplicity should also be present in research. Primary care undoubtedly needs more research and research needs more primary care. Both our research question and the methodology used to answer this question should be as straightforward as possible. As Einstein put it, our theories should be ‘as simple as possible but no simpler.’ As a member of the Editorial Board of the European Journal of General Practice, I can clearly state that we sometimes receive complex research studies or papers that are complicated and dull to read. Complex studies also undermine the clinicians’ confidence. Take, for example, the composite outcomes used in many papers in cardiovascular medicine. As Cordoba et al., mention in their landmark paper, a drug that leads to a large reduction in a composite outcome of ‘death and chest pain;’ their finding could mean that the drug resulted in fewer deaths and less chest pain but it is possible that the composite is driven entirely by a reduction in chest pain with no change or even an increase in death [8]. When writing a paper we should be as simple as possible. As with all other types of writing, complicated articles also have to be written with the reader profile in mind. One needs to focus on a particular topic and write strictly within the scope of such confines, and one has to be realistic when setting these boundaries. An excellent article is not one that is more complicated; a good article makes the reader think and can create discussion. Like a brilliant speaker, a speech should reflect the level of the audience and the audience has to be able to understand what the speaker says because complex speeches can easily become dry and dull if not handled carefully. Presenting evidence and recommendations in a clear, concise, accessible, flexible and simple format facilitates the retrieval and assimilation of specific information. Therefore, simple language, unambiguity, relevancy of content, and clarity of structure and logic in the document are crucial to ensure that the information flows and that the subject matter is easily understood by the people who need to understand it and to make the right decisions. Not everyone considers the same degree of simplicity a theory, a guideline, an algorithm, a piece of research, etc. Something simple in one approach may seem complex in another, suggesting that simplicity lies in the eye of the beholder. Anyone can make things bigger and more complex. However, being as simple as possible is the wisest, albeit not necessarily the easiest, choice for being successful. It takes talent and courage to move this way. Keeping things simple should be mandatory in primary care.

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          Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review

          Objective To study how composite outcomes, which have combined several components into a single measure, are defined, reported, and interpreted. Design Systematic review of parallel group randomised clinical trials published in 2008 reporting a binary composite outcome. Two independent observers extracted the data using a standardised data sheet, and two other observers, blinded to the results, selected the most important component. Results Of 40 included trials, 29 (73%) were about cardiovascular topics and 24 (60%) were entirely or partly industry funded. Composite outcomes had a median of three components (range 2–9). Death or cardiovascular death was the most important component in 33 trials (83%). Only one trial provided a good rationale for the choice of components. We judged that the components were not of similar importance in 28 trials (70%); in 20 of these, death was combined with hospital admission. Other major problems were change in the definition of the composite outcome between the abstract, methods, and results sections (13 trials); missing, ambiguous, or uninterpretable data (9 trials); and post hoc construction of composite outcomes (4 trials). Only 24 trials (60%) provided reliable estimates for both the composite and its components, and only six trials (15%) had components of similar, or possibly similar, clinical importance and provided reliable estimates. In 11 of 16 trials with a statistically significant composite, the abstract conclusion falsely implied that the effect applied also to the most important component. Conclusions The use of composite outcomes in trials is problematic. Components are often unreasonably combined, inconsistently defined, and inadequately reported. These problems will leave many readers confused, often with an exaggerated perception of how well interventions work.
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            Words matter: increasing the implementation of clinical guidelines.

            To determine whether writing clinical guideline recommendations in behaviourally specified "plain English" language increases the likelihood of their implementation by service users (patients). Randomised controlled trial in which participants received either the original text of the National Institute for Clinical Excellence (NICE) public guidelines for the management of schizophrenia or a behaviourally specified text with the same content. Mental health service user networks and voluntary sector organisations within two inner London boroughs. Eighty four mental health service users recruited by post or face to face contact at service user meetings. The section of the NICE public guidelines for schizophrenia concerning psychological and pharmacological treatments was rewritten to improve style and behavioural specificity by applying evidence-based and psychologically informed principles of good written communication. Cognitive predictors of behaviour, as specified by the evidence based theory of planned behaviour, constituted the primary outcome as it was not possible to measure the actual behaviour of guideline implementation. The predictors were behavioural intentions to implement the guidelines, attitudes towards implementation, and perceived behavioural control over implementation. Satisfaction with the guidelines and perceived comprehension were also measured. Behaviourally specified "plain English" guidelines led to stronger intentions to implement the guidelines, more positive attitudes towards them, and greater perceived behavioural control over using them. There was no difference in satisfaction or perceived comprehension. Writing guidelines with high behavioural specificity in conjunction with the use of "plain English" may be a simple and effective method of increasing their implementation. Evaluation with a behavioural outcome is now needed.
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              The right care, every time: improving adherence to evidence-based guidelines.

              Guidelines are integral to reducing variation in paediatric care by ensuring that children receive the right care, every time. However, for reasons discussed in this paper, clinicians do not always follow evidence-based guidelines. Strategies to improve guideline usage tend to focus on dissemination and education. These approaches, however, do not address some of the more complex factors that influence whether a guideline is used in clinical practice. In this article, part of the Equipped Quality Improvement series, we outline the literature on barriers to guideline adherence and present practical solutions to address these barriers. Examples outlined include the use of care bundles, integrated care pathways and quality improvement collaboratives. A sophisticated information technology system can improve the use of evidence-based guidelines and provide organisations with valuable data for learning and improvement. Key to success is the support of an organisation that places reliability of service delivery as the way business is done. To do this requires leadership from clinicians in multidisciplinary teams and a system of continual improvement. By learning from successful approaches, we believe that all healthcare organisations can ensure the right care for each patient, every time.
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                Author and article information

                Journal
                Eur J Gen Pract
                Eur J Gen Pract
                IGEN
                igen20
                The European Journal of General Practice
                Taylor & Francis
                1381-4788
                1751-1402
                2019
                10 July 2019
                : 25
                : 3
                : 99-100
                Affiliations
                Via Roma Primary Healthcare Centre , Barcelona, Spain
                Author notes
                Article
                1635368
                10.1080/13814788.2019.1635368
                6713114
                31290346
                4a54a5cb-ff3f-48ed-b77b-10a450771e8a
                © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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                Figures: 0, Tables: 0, Pages: 2, Words: 1446
                Categories
                Editorial

                Medicine
                Medicine

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