Advances in studies on schistosome-host interactions mediated by extracellular vesicles

Abstract

Extracellular vesicles (EVs) are minute particles secreted by the cells of living organisms, which can encapsulate various bioactive molecules for long-distance transport to present biological functions. With the recent studies on parasite-host interactions, EVs, as a carrier for long-distance transport of worm-derived molecules, have been paid much attention during the across-species regulation of hosts. During schistosome infections, adult worms and eggs have been found to mediate hosts via secretion of EVs. This review presents the advances in the studies on schistosome-host interactions mediated by EVs.

Abstract

［摘要］ 细胞外囊泡是一类由活细胞分泌的囊泡小体, 可以包裹各类生物活性分子远距运输并发挥生物学功能。近年来, 随着寄生虫-宿主相互作用研究的深入, 细胞外囊泡作为寄生虫远距离运输虫源性分子的载体, 可实现对宿主进行跨物种调控而受到广泛关注。在血吸虫感染过程中, 成虫及虫卵可以通过分泌细胞外囊泡对宿主进行调控。本文就细胞外囊泡介导的血吸虫-宿主相互作用研究进展作一综述。