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      Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.

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          Abstract

          Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jun 13 1997
          : 276
          : 5319
          Affiliations
          [1 ] Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan. tanaka@ncnaxp.ncap.go.jp
          Article
          10.1126/science.276.5319.1699
          9180080
          4a66b57b-cf07-45de-908b-0f83467be12f
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