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      Binary and graded responses in gene networks.

      Science's STKE : signal transduction knowledge environment
      Animals, Gene Expression Regulation, genetics, Gene Expression Regulation, Enzymologic, Genes, Regulator, MAP Kinase Signaling System, Signal Transduction

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          Abstract

          Although gene expression can be regulated in a graded or a binary fashion, the majority of eukaryotic genes are either fully activated or not expressed at all in individual cells. This binary response might be an inherent property of many eukaryotic promoters. Analysis of transcription under the control of yeast GAL1 promoter suggests, however, that graded and binary modes of transcription are not mutually exclusive, but that both can occur at the same promoter when the activity of different signaling pathways is varied. In view of that, it can be expected that forthcoming experimental studies on the combinatorial effects of signaling and transcriptional mechanisms will reveal new strategies for generating graded or binary responses.

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          Author and article information

          Journal
          12149512
          10.1126/stke.2002.143.pe33

          Chemistry
          Animals,Gene Expression Regulation,genetics,Gene Expression Regulation, Enzymologic,Genes, Regulator,MAP Kinase Signaling System,Signal Transduction

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