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      Neuronal prediction of opponent's behavior during cooperative social interchange in primates.

      1 , 2
      Cell

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          Abstract

          A cornerstone of successful social interchange is the ability to anticipate each other's intentions or actions. While generating these internal predictions is essential for constructive social behavior, their single neuronal basis and causal underpinnings are unknown. Here, we discover specific neurons in the primate dorsal anterior cingulate that selectively predict an opponent's yet unknown decision to invest in their common good or defect and distinct neurons that encode the monkey's own current decision based on prior outcomes. Mixed population predictions of the other was remarkably near optimal compared to behavioral decoders. Moreover, disrupting cingulate activity selectively biased mutually beneficial interactions between the monkeys but, surprisingly, had no influence on their decisions when no net-positive outcome was possible. These findings identify a group of other-predictive neurons in the primate anterior cingulate essential for enacting cooperative interactions and may pave a way toward the targeted treatment of social behavioral disorders.

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          Author and article information

          Journal
          Cell
          Cell
          1097-4172
          0092-8674
          Mar 12 2015
          : 160
          : 6
          Affiliations
          [1 ] Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02114, USA; Department of Neurosurgery, MGH-HMS Center for Nervous System Repair, Harvard Medical School, Boston, MA 02114, USA. Electronic address: haroush.keren@mgh.harvard.edu.
          [2 ] Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02114, USA; Department of Neurosurgery, MGH-HMS Center for Nervous System Repair, Harvard Medical School, Boston, MA 02114, USA. Electronic address: zwilliams@mgh.harvard.edu.
          Article
          S0092-8674(15)00123-3 NIHMS668054
          10.1016/j.cell.2015.01.045
          4364450
          25728667
          4a75294e-7b55-4af2-854d-efc001f2eb21
          Copyright © 2015 Elsevier Inc. All rights reserved.
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