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      Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones.

      Science (New York, N.Y.)
      Amino Acid Sequence, Animals, Contraceptives, Oral, pharmacology, Follicle Stimulating Hormone, secretion, Hypothalamus, analysis, physiology, Luteinizing Hormone, blood, Male, Peptides, chemical synthesis, isolation & purification, Pituitary Gland, Pituitary Hormone-Releasing Hormones, Rats, Swine

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          Abstract

          A polypeptide isolated from porcine hypothalami stimulates the release of both luteinizing hormone and follicle-stimulating hormone from the pituitaries of several species. This polypeptide has been structurally identified as (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2) and synthesized. The natural and synthetic materials share biological properties. It appears that this peptide represents the hypothalamic hormone regulating the secretion of both luteinizing hormone and follicle-stimulating hormone.

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