Malnutrition and Cachexia in Heart Failure.

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Abstract

Heart failure is a growing public health concern. Advanced heart failure is frequently associated with severe muscle wasting, termed cardiac cachexia This process is driven by systemic inflammation and tumor necrosis factor in a manner common to other forms of disease-related wasting seen with cancer or human immunodeficiency virus. A variable degree of malnutrition is often superimposed from poor nutrient intake. Cardiac cachexia significantly decreases quality of life and survival in patients with heart failure. This review outlines the evaluation of nutrition status in heart failure, explores the pathophysiology of cardiac cachexia, and discusses therapeutic interventions targeting wasting in these patients.

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Journal

Journal ID (iso-abbrev): JPEN J Parenter Enteral Nutr

Title: JPEN. Journal of parenteral and enteral nutrition

Publisher: SAGE Publications

ISSN (Electronic): 1941-2444

ISSN (Print): 0148-6071

Publication date (Electronic): May 2016

Volume: 40

Issue: 4

Affiliations

[1 ] University of Western Ontario, London, Ontario, Canada Lawson Health Research Institute Program of Experimental Medicine (POEM), London, Ontario, Canada.

[2 ] University of Western Ontario, London, Ontario, Canada.

[3 ] Department of Medicine, University of Toronto, Ancaster, Ontario, Canada Department of Nutritional Sciences, University of Toronto, Ancaster, Ontario, Canada Department of Physiology, University of Toronto, Ancaster, Ontario, Canada.

[4 ] Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

[5 ] Department of Anesthesia, Section on Critical Care, Wake Forest School of Medicine, Winston-Salem, North Carolina ragarwal@wakehealth.edu.

Article

Publisher Item ID: 0148607114566854

DOI: 10.1177/0148607114566854

PubMed ID: 25634161

SO-VID: 4ab89a8d-303e-41d8-ac4e-f307e8918b2a

History

Keywords: organ transplantation,nutrition assessment,internal medicine,minerals/trace elements,nutrition,outcomes research/quality,research and diseases,vitamins,cardiac disease,proteins,critical care,nutrition support practice

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Keywords: organ transplantation, nutrition assessment, internal medicine, minerals/trace elements, nutrition, outcomes research/quality, research and diseases, vitamins, cardiac disease, proteins, critical care, nutrition support practice

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