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      Targeting EGFR in lung cancer: Lessons learned and future perspectives

      research-article
      , MD, , MD
      Molecular aspects of medicine
      EGFR, NSCLC, Lung Cancer

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          Abstract

          The development of individualized therapies has become the focus of current oncology research. Precision medicine has demonstrated great potential for bringing safe and effective drugs to those patients stricken with cancer, and is becoming a reality as more oncogenic drivers of malignancy are discovered. The discovery of Epidermal Growth Factor Receptor ( EGFR) mutations as a driving mutation in non-small cell lung cancer (NSCLC) and the subsequent success of the tyrosine kinase inhibitors (TKI) have led the way for NSCLC to be at the forefront of biomarker-based drug development. However, this direction was not always so clear, and this article describes the lessons learned in targeted therapy development from EGFR in NSCLC.

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          Author and article information

          Journal
          7603128
          5672
          Mol Aspects Med
          Mol. Aspects Med.
          Molecular aspects of medicine
          0098-2997
          1872-9452
          30 August 2016
          27 May 2015
          November 2015
          01 November 2016
          : 45
          : 67-73
          Affiliations
          Winship Cancer Institute, Emory University, GA
          Author notes
          [2 ]Corresponding author: Professor, Director of Medical Oncology, 1365 Clifton Road NE, Rm C-3090, Atlanta, GA 30322, suresh.ramalingam@ 123456emory.edu , Phone: 404-778-5378, Fax: 404-778-5520
          [1]

          1365C Clifton Road NE, Atlanta, GA 30322, csteuer@ 123456emory.edu , Phone: (914) 318-9363, Fax: (404) 778-1353

          Article
          PMC5024712 PMC5024712 5024712 nihpa697022
          10.1016/j.mam.2015.05.004
          5024712
          26022942
          4ada79d3-a101-4d47-870d-5da9564a7fe0
          History
          Categories
          Article

          Lung Cancer,NSCLC,EGFR
          Lung Cancer, NSCLC, EGFR

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