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      Travel-Related Antimicrobial Resistance: A Systematic Review

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          Abstract

          There is increasing evidence that human movement facilitates the global spread of resistant bacteria and antimicrobial resistance (AMR) genes. We systematically reviewed the literature on the impact of travel on the dissemination of AMR. We searched the databases Medline, EMBASE and SCOPUS from database inception until the end of June 2019. Of the 3052 titles identified, 2253 articles passed the initial screening, of which 238 met the inclusion criteria. The studies covered 30,060 drug-resistant isolates from 26 identified bacterial species. Most were enteric, accounting for 65% of the identified species and 92% of all documented isolates. High-income countries were more likely to be recipient nations for AMR originating from middle- and low-income countries. The most common origin of travellers with resistant bacteria was Asia, covering 36% of the total isolates. Beta-lactams and quinolones were the most documented drug-resistant organisms, accounting for 35% and 31% of the overall drug resistance, respectively. Medical tourism was twice as likely to be associated with multidrug-resistant organisms than general travel. International travel is a vehicle for the transmission of antimicrobial resistance globally. Health systems should identify recent travellers to ensure that adequate precautions are taken.

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          Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

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            Mobile Genetic Elements Associated with Antimicrobial Resistance

            SUMMARY Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world. It is now abundantly clear that both Gram-negative and Gram-positive bacteria are able to meet the evolutionary challenge of combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from the bacterial gene pool. This is achieved through the concerted activities of mobile genetic elements able to move within or between DNA molecules, which include insertion sequences, transposons, and gene cassettes/integrons, and those that are able to transfer between bacterial cells, such as plasmids and integrative conjugative elements. Together these elements play a central role in facilitating horizontal genetic exchange and therefore promote the acquisition and spread of resistance genes. This review aims to outline the characteristics of the major types of mobile genetic elements involved in acquisition and spread of antibiotic resistance in both Gram-negative and Gram-positive bacteria, focusing on the so-called ESKAPEE group of organisms ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacter spp., and Escherichia coli ), which have become the most problematic hospital pathogens.
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              Understanding the mechanisms and drivers of antimicrobial resistance.

              To combat the threat to human health and biosecurity from antimicrobial resistance, an understanding of its mechanisms and drivers is needed. Emergence of antimicrobial resistance in microorganisms is a natural phenomenon, yet antimicrobial resistance selection has been driven by antimicrobial exposure in health care, agriculture, and the environment. Onward transmission is affected by standards of infection control, sanitation, access to clean water, access to assured quality antimicrobials and diagnostics, travel, and migration. Strategies to reduce antimicrobial resistance by removing antimicrobial selective pressure alone rely upon resistance imparting a fitness cost, an effect not always apparent. Minimising resistance should therefore be considered comprehensively, by resistance mechanism, microorganism, antimicrobial drug, host, and context; parallel to new drug discovery, broad ranging, multidisciplinary research is needed across these five levels, interlinked across the health-care, agriculture, and environment sectors. Intelligent, integrated approaches, mindful of potential unintended results, are needed to ensure sustained, worldwide access to effective antimicrobials.
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                Author and article information

                Journal
                Trop Med Infect Dis
                Trop Med Infect Dis
                tropicalmed
                Tropical Medicine and Infectious Disease
                MDPI
                2414-6366
                16 January 2021
                March 2021
                : 6
                : 1
                : 11
                Affiliations
                [1 ]School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia; kpan4827@ 123456uni.sydney.edu.au (K.N.A.P.); grant.hill-cawthorne@ 123456sydney.edu.au (G.A.H.-C.)
                [2 ]University Medical Center, Umm Al-Qura University, Al Jamiah, Makkah, Makkah Region 24243, Saudi Arabia
                [3 ]The Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Westmead, NSW 2145, Australia; harunor.rashid@ 123456health.nsw.gov.au (H.R.); or moataz.mohamed19@ 123456outlook.com (M.A.E.G.)
                [4 ]The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia
                [5 ]National Centre for Immunisation Research and Surveillance (NCIRS), Kids Research, The Children’s Hospital at Westmead, Westmead, NSW 2145, Australia
                [6 ]The Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia
                Author notes
                [†]

                These authors contributed equally to the work.

                Author information
                https://orcid.org/0000-0001-9533-0720
                https://orcid.org/0000-0001-6339-915X
                https://orcid.org/0000-0003-2286-5139
                https://orcid.org/0000-0002-0020-261X
                https://orcid.org/0000-0002-3828-5473
                Article
                tropicalmed-06-00011
                10.3390/tropicalmed6010011
                7838817
                33467065
                4aee6739-7c39-4c49-bda6-d3bea9a0dfc8
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 01 December 2020
                : 11 January 2021
                Categories
                Review

                travel,antimicrobial resistance,medical traveller,enteric bacteria,multidrug resistance

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