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Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies

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      BackgroundGenetic variations in vitamin D receptor (VDR) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between VDR BsmI gene polymorphism and TB risk, but yielded inconclusive results.Methodology/Principal FindingsWe performed a comprehensive meta-analysis of 15 publications with a total of 2309 cases and 3568 controls. We assessed the strength of the association between VDR BsmI gene polymorphism and TB risk and performed sub-group analyses by ethnicity, sample size and Hardy–Weinberg equilibrium (HWE). We found a statistically significant correlation between VDR BsmI gene polymorphism and decreased TB risk in four comparison models: allele model (b vs. B: OR = 0.78, 95% CI = 0.67, 0.89; Pheterogeneity = 0.004), homozygote model (bb vs. BB: OR = 0.61, 95% CI = 0.43, 0.87; Pheterogeneity = 0.001), recessive model (bb vs. Bb+BB: OR = 0.70, 95% CI = 0.56, 0.88; Pheterogeneity = 0.005) and dominant model (bb+Bb vs. BB: OR = 0.77, 95% CI = 0.61, 0.97; Pheterogeneity = 0.010), especially in studies based on Asian population. Sub-group analyses also revealed that there was a statistically decreased TB risk in “small” studies (<500 participants) and studies with PHWE>0.5. Meta-regression and stratification analysis both showed that the ethnicity and sample size contributed to heterogeneity.ConclusionsThis meta-analysis suggests that VDR BsmI gene polymorphism is associated with a significant decreased TB risk, especially in Asian population.

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            Author and article information

            [1 ]Department of Pharmacy, Changzhou Third People’s Hospital, Changzhou, China
            [2 ]College of Pharmacy, Soochow University, Suzhou, China
            [3 ]The Fourth Clinical College of Nanjing Medical University, Nanjing, China
            [4 ]Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China
            [5 ]Department of Bio-statistics, Georgia Health Science University, Augusta, Georgia, United States of America
            [6 ]Department of Pharmacy, Changzhou First People’s Hospital, Changzhou, China
            [7 ]Department of Pulmonary Tuberculosis, Changzhou Third People’s Hospital, Changzhou, China
            Fundacion Huesped, Argentina
            Author notes

            Competing Interests: The authors have declared that no competing interests exist.

            Conceived and designed the experiments: YJW XY LX FLT. Performed the experiments: YJW XY XXW YZY ZXZ SMZ LX FLT. Analyzed the data: YJW XY XXW. Contributed reagents/materials/analysis tools: YJW XY XXW MTQ. Wrote the paper: YJW XY XXW. Access to full-text article: YJW XY.

            Role: Editor
            PLoS One
            PLoS ONE
            PLoS ONE
            Public Library of Science (San Francisco, USA )
            25 June 2013
            : 8
            : 6

            This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

            Pages: 8
            The authors have no support or funding to report.
            Research Article
            Population Genetics
            Genetic Polymorphism
            Population Biology
            Population Genetics
            Genetic Polymorphism
            Clinical Research Design
            Genetic Epidemiology
            Infectious Disease Epidemiology
            Infectious Diseases
            Bacterial Diseases
            Non-Clinical Medicine
            Health Care Policy
            Health Risk Analysis



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