Blog
About

14
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Suberitine A-D, four new cytotoxic dimeric aaptamine alkaloids from the marine sponge Aaptos suberitoides.

      Organic Letters

      chemistry, isolation & purification, pharmacology, Animals, Antineoplastic Agents, Drug Screening Assays, Antitumor, Leukemia P388, Marine Biology, Mice, Molecular Structure, Naphthyridines, Nuclear Magnetic Resonance, Biomolecular, Porifera, Alkaloids

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Suberitine A-D (1-4), four new bis-aaptamine alkaloids with two aaptamine skeleton units, 8,9,9-trimethoxy-9H-benzo[de][1,6]-naphthyridine and demethyl(oxy)-aaptamine, linked through a rare C-3-C-3' or C-3-C-6' σ-bond between the 1,6-naphthyridine rings, together with two known monomers 5 and 6, were isolated from the marine sponge Aaptos suberitoides. Their structures were elucidated using NMR spectroscopy. Compounds 2 and 4 showed potent cytotoxicity against P388 cell lines, with IC(50) values of 1.8 and 3.5 μM, respectively. © 2012 American Chemical Society

          Related collections

          Author and article information

          Journal
          22472093
          10.1021/ol3004589

          Comments

          Comment on this article