Efficient conversion of grazed pasture and supplementary feeds into milk is essential to the profitability of dairy farming in southern Australia as costs of production continue to rise. The application of diet formulation approaches to the nutritional management of grazing dairy cows provides unique challenges in predicting the interactions that occur between grazed herbage and supplementary feeds. How feed intake and associative effects between feeds in lactating dairy cows grazing pasture might affect estimated metabolisable energy supplied by the diet are examined. The effects of increasing feed intake in high-producing dairy cows on decreasing the digestibility of energy, and the compensatory effects of reduced methane production, are reviewed. The factors affecting intake of grazing cows and possible effects on digestibility are considered, and include characteristics of the pasture/forage and amounts and forms of concentrates. Estimates of the potential magnitude of negative associative effects in dairy cows have been made using 2 datasets from recent experiments. Finally, the potential importance of understanding and predicting the magnitude of associative effects for efficient pasture-based dairy production is discussed. It is concluded that although associative effects between feeds in grazing dairy cows cannot be predicted with certainty, and although they involve complex interactions among a number of variables, ignoring their occurrence can lead to significant errors in both feed evaluation and ration formulation.