Amplified gut feelings under inflammation and depressed mood: A randomized fMRI trial on interoceptive pain in healthy volunteers.

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Abstract

Inflammation and depressed mood constitute clinically relevant vulnerability factors for enhanced interoceptive sensitivity and chronic visceral pain, but their putative interaction remains untested in human mechanistic studies. We tested interaction effects of acute systemic inflammation and sad mood on the expectation and experience of visceral pain by combining experimental endotoxemia with a mood induction paradigm.

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Journal

Journal ID (iso-abbrev): Brain Behav Immun

Title: Brain, behavior, and immunity

Publisher: Elsevier BV

ISSN (Electronic): 1090-2139

ISSN (Print): 0889-1591

Publication date (Electronic): Aug 2023

Volume: 112

Affiliations

[1 ] Institute of Medical Psychology and Behavioral Immunobiology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Institute for Medical Education, University Hospital Essen, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: sven.benson@uk-essen.de.

[2 ] Department of Medical Psychology and Medical Sociology, Ruhr University Bochum, Germany.

[3 ] Institute of Medical Psychology and Behavioral Immunobiology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

[4 ] Institute of Medical Psychology and Behavioral Immunobiology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Department of Neurology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

[5 ] Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

[6 ] Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

[7 ] Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

[8 ] Department of Medical Psychology and Medical Sociology, Ruhr University Bochum, Germany; Department of Neurology, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Article

Publisher Item ID: S0889-1591(23)00147-2

DOI: 10.1016/j.bbi.2023.06.005

PubMed ID: 37302437

SO-VID: 4b15b369-ea1c-4c20-bf92-085218c617f8

History

Keywords: Anticipation,Cytokines,Depression,Endotoxin,Inflammation,Interoception,Lipopolysaccharide,Mood,Nocebo,Visceral pain

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Keywords: Anticipation, Cytokines, Depression, Endotoxin, Inflammation, Interoception, Lipopolysaccharide, Mood, Nocebo, Visceral pain

Amplified gut feelings under inflammation and depressed mood: A randomized fMRI trial on interoceptive pain in healthy volunteers.

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