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      Influence of Prolonged Corticosteroid Therapy on the Outcome of Steroid-Responsive Nephrotic Syndrome

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          Eighty-six patients (59 males and 27 females) diagnosed with steroid-responsive nephrotic syndrome during childhood were identified. The patients were 20–40 years of age (mean 27.0 ± 5.0) with a mean follow-up period of 19.5 ± 5.9 years. All patients had been treated with a long-term tapering corticosteroid therapy. Thirty patients had also received a course of cyclophosphamide (2 mg/kg/day for 12 weeks). Sixty-six had achieved sustained remission off corticosteroids, while 20 were still receiving corticosteroids to maintain remission. None of the 86 patients had proteinuria or renal insufficiency at the time of the study. Mean final heights in males and females were similar (–0.51 ± 1.21 and –0.23 ± 1.16 standard deviation score). Mean final height of 20 steroid-dependent patients was significantly less than that of 66 in remission off corticosteroids (p < 0.005). Ten cyclophosphamide-treated patients got married and 9 had at least 1 healthy child. In children with steroid-responsive nephrotic syndrome, the need for corticosteroid therapy to maintain remission may be associated with decreased adult height. Patients who received a 12-week course of cyclophosphamide are likely to be normally fertile as adults.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          October 2001
          19 October 2001
          : 21
          : 5
          : 362-367
          aDepartment of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama; bInaba Pediatric Clinic, Toyama; cDepartment of Pediatrics, Niigata Prefectural Yoshida Hospital, Niigata; dDepartment of Pediatrics, Toyama National Sanitarium Hospital, Toyama; eTakada Pediatric Clinic, Niigata, and fDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan
          46275 Am J Nephrol 2001;21:362–367
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 2, Tables: 1, References: 27, Pages: 6
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