6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease.

      American journal of respiratory and critical care medicine
      Administration, Inhalation, Administration, Oral, Adrenergic beta-Agonists, administration & dosage, therapeutic use, Age Factors, Aged, Anti-Inflammatory Agents, Beclomethasone, Confidence Intervals, Cross-Sectional Studies, Evaluation Studies as Topic, Forced Expiratory Volume, Glucocorticoids, Humans, Logistic Models, Lung Diseases, Obstructive, drug therapy, Male, Middle Aged, Odds Ratio, Osteoporosis, chemically induced, Prednisone, Prevalence, Smoking, physiopathology, Spinal Fractures, Triamcinolone Acetonide, Vital Capacity

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Osteoporosis is a major complication of long-term corticosteroid administration, but the magnitude of the effect in patients with chronic obstructive pulmonary disease (COPD) is not well defined. In a cross-sectional study, we evaluated the association between steroid use and vertebral fractures in 312 men, 50 yr of age or older, with COPD. Subjects were evaluated according to their corticosteroid use: Never Steroid Users (NSU) (n = 117), Inhaled Steroid Users (ISU) (n = 70), and Systemic Steroid Users (SSU) (n = 125). The prevalence of one or more vertebral fractures was 48.7% in the NSU group, 57.1% in the ISU group, and 63.3% in the SSU group. Compared with NSU, SSU were two times as likely to have one or more vertebral fractures: age-adjusted odds ratio (OR) = 1.80; 95% CI, 1.08 to 3.07. This relationship was primarily due to a strong association between continuous systemic steroid use and vertebral fractures: age-adjusted OR = 2.36; 95% CI, 1.26 to 4.38. In addition, fractures in SSU were more likely to be multiple and more severe. A weaker relationship existed between inhaled steroid use and vertebral fractures: age-adjusted OR = 1.35; 95% CI, 0.77 to 2.56 compared with NSU. These data indicate that vertebral fractures are common in older men with COPD; the likelihood of these fractures is greatest in those men using continuous systemic steroids.

          Related collections

          Author and article information

          Comments

          Comment on this article