Tumorigenicity of citrinin in male F344 rats.

This study reports on the tumorigenicity of citrinin, a nephrotoxic mycotoxin. Male F344 rats were fed 0.1% citrinin in the diet for up to 80 weeks. The first renal tumor was seen grossly in a rat receiving citrinin which was killed at week 52. Histopathology of the kidneys showed renal adenomas in 35 of 48 (72.9%) rats that survived after 40 weeks. No renal tumors were seen in the control rats.