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      Referente al documento de posición de la SEIOMM sobre COVID-19 y vitamina D Translated title: Regarding the position paper of the SEIOMM on COVID-19 and vitamin D

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          Benefit-risk assessment of vitamin D supplementation.

          Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose-response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30-44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk. Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
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            Is calcifediol better than cholecalciferol for vitamin D supplementation?

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              Vitamin D supplementation: upper limit for safety revisited?

              R. Rizoli (2021)
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                Author and article information

                Journal
                romm
                Revista de Osteoporosis y Metabolismo Mineral
                Rev Osteoporos Metab Miner
                Sociedad Española de Investigaciones Óseas y Metabolismo Mineral (Madrid, Madrid, Spain )
                1889-836X
                2173-2345
                June 2021
                : 13
                : 2
                : 102
                Affiliations
                [01] Valladolid orgnameHospital Universitario Río Hortega orgdiv1Servicio de Medicina Interna España
                Article
                S1889-836X2021000200010 S1889-836X(21)01300200010
                10.4321/s1889-836x2021000200010
                4b43559e-be70-4454-a0be-dee84b0f6f07

                This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.

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