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      Microdosing and drug development: past, present and future.

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          Abstract

          Microdosing is an approach to early drug development where exploratory pharmacokinetic data are acquired in humans using inherently safe sub-pharmacologic doses of drug. The first publication of microdose data was 10 years ago and this review comprehensively explores the microdose concept from conception, over the past decade, up until the current date.

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          Author and article information

          Journal
          Expert Opin Drug Metab Toxicol
          Expert opinion on drug metabolism & toxicology
          1744-7607
          1742-5255
          Jul 2013
          : 9
          : 7
          Affiliations
          [1 ] University of Lincoln, Brayford Pool, Lincoln, LN6 7TS, UK. glappin@lincoln.ac.uk
          Article
          NIHMS712835
          10.1517/17425255.2013.786042
          23550938
          4b4ac2b9-526c-4a9f-aabb-b50427a8b72d
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