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      Changes in Plasma Cholesterol Levels after Hospitalization for Acute Coronary Events

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          To retrospectively assess the changes in total cholesterol levels after a hospital admission for an acute coronary event, 287 patients were identified who had one isolated event: 130 patients with acute myocardial infarction, 122 patients after coronary artery bypass graft surgery, 35 patients after percutaneous transluminal coronary angioplasty. To be included, patients had to have a total cholesterol measurement within the 3 months prior to hospitalization and periodically after the acute coronary event. Total cholesterol measurements were recorded during four time periods: 0-3 months before hospital admission (baseline); and 0-3, 3-6, and 6-9 months after the hospitalization. Mean total cholesterol value was used if a patient had multiple measurements during a time period. Results: There was no significant difference in the baseline total cholesterol levels among the three groups (acute myocardial infarction, coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty). In all three groups, there was a decrease in total cholesterol level after hospital admission compared to baseline (p < 0.0001). This decrease was significantly greater in coronary artery bypass graft surgery patients compared to the other two groups. Total cholesterol levels returned to baseline levels by 3 months after the hospitalization in all three groups. Total cholesterol decreased significantly from baseline in patients after an acute myocardial infarction; this decrease was significantly greater if they received thrombolytic therapy (p < 0.05). Total cholesterol returned to baseline 3 months after hospitalization in both groups. Conclusions: During the 3 months following hospital admission for an acute coronary event, total cholesterol levels are not representative of the patient’s baseline values. Management of hypercholesterolemia in this setting requires the use of baseline (preadmission) total cholesterol values.

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          Author and article information

          S. Karger AG
          19 November 2008
          : 87
          : 3
          : 194-199
          Department of Medicine, Emory University School of Medicine, Medical Service, Grady Memorial Hospital, and the Emory University School of Public Health, Atlanta, Ga., USA
          177086 Cardiology 1996;87:194–199
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 6
          General Cardiology

          General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology


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