- Record: found
- Abstract: not found
- Article: not found
The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
In native brain membranes the principal excitatory neurotransmitter L-glutamate activates
cation-conducting channels with distinct biophysical and pharmacological properties.
Molecular cloning has revealed the existence of 16 channel subunits that can assemble
in homomeric or heteromeric configurations in vitro to form receptor channels with
disparate functional properties. This review describes the different channel types
obtained by recombinant means and the genetic mechanisms controlling the expression
of functionally important channel structures.