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      Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat.

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          Abstract

          Microvascular dysfunction posttreatment of stroke with recombinant human tissue-type plasminogen activator (rht-PA) constrains the therapeutic window to 3 hours. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) promote vascular thrombolysis and reduce the inflammation response. We therefore investigated the neuroprotective effects of a combination of atorvastatin and delayed rht-PA treatment in a rat model of embolic stroke.

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          Author and article information

          Journal
          Circulation
          Circulation
          Ovid Technologies (Wolters Kluwer Health)
          1524-4539
          0009-7322
          Nov 29 2005
          : 112
          : 22
          Affiliations
          [1 ] Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA.
          Article
          112/22/3486
          10.1161/CIRCULATIONAHA.104.516757
          16316970
          4b69eabb-d06d-40f1-bdd9-a48fbcb61ef4

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