Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics.

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Abstract

Lipid exchange among citrem nanoparticles and an ethanol micellar solution containing soy phosphatidylcholine was investigated in situ by coupling small angle X-ray scattering with a microfluidic device. The produced soy phosphatidylcholine/citrem nanoparticles have great potential in the development of hemocompatible nanocarriers for drug delivery.

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Journal

Journal ID (iso-abbrev): Analyst

Title: The Analyst

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 1364-5528

ISSN (Print): 0003-2654

Publication date (Electronic): Jul 26 2017

Affiliations

[1 ] Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark. anan.yaghmur@sund.ku.dk.

[2 ] Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark. anan.yaghmur@sund.ku.dk and Niels Bohr Institute, University of Copenhagen, Denmark, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark.

[3 ] Elettra-Sincrotrone Trieste, Strada Statale 14, 34149 Basovizza, Trieste, Italy.

[4 ] Niels Bohr Institute, University of Copenhagen, Denmark, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark.

[5 ] Laboratory for Biointerfaces, Department of Materials of Meet Life, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland. Stefan.Salentinig@empa.ch stefan.salentinig@gmail.com.

Article

DOI: 10.1039/c7an00860k

PubMed ID: 28744529

SO-VID: 4b738923-b693-413c-9fbb-1137dc53c20d

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