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      In situ Hybridization Analysis of Cytomegalovirus and Adenovirus DNA in Immunoglobulin A Nephropathy

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          Abstract

          Viruses are thought to play a role in the occurrence of IgA nephropathy. In fact, cytomegalovirus (CMV) antigens have been detected in the glomerular mesangium. To clarify this relationship, we used in situ hybridization with biotin-labeled DNA probes of CMV and adenovirus (AV) in 40 patients with IgA nephropathy to determine the presence or absence of virus in affected renal tissue. Renal tissue DNA from these patients did not hybridize with the CMV or AV probes. Our results fail to support the theory that consecutive regional renal infections with CMV and/or AV are involved in the pathogenesis of IgA nephropathy.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1992
          1992
          12 December 2008
          : 62
          : 2
          : 166-168
          Affiliations
          Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
          Article
          187027 Nephron 1992;62:166–168
          10.1159/000187027
          1331834
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Original Paper

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