Subjects (n = 23) performed three 3 x 8 seated leg press workouts on a flywheel ergometer to note the net caloric cost. This study's purpose was to examine net caloric cost as a function of total work on an inertial resistance exercise device offering more eccentric loading than conventional isotonic weight training equipment. High intraclass correlations for net caloric cost (0.89) and total work (0.94) result from data collected from 3 workouts. Average total work and net caloric cost values reveal a significant (r = 0.62, p < 0.05) correlation yielding the following equation: predicted net caloric cost = 33.2 + 0.006014331 (total work). Current study data also show favorable net caloric cost (1.24 kcal x kg(-1) x d(-1)), exercise efficiency (9.48 kcal x 10(-3) per joule), and estimated mechanical loading (65 W min x kg(-1) LBM x d(-1)) values. The results of the current study serve as baseline knowledge for exercise prescriptions pertaining to net caloric cost, exercise efficiency, and mechanical loading using this device.