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      Regulation of the mevalonate pathway

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      Nature
      Springer Science and Business Media LLC

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          Abstract

          The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          1476-4687
          February 1990
          February 1990
          : 343
          : 6257
          : 425-430
          Article
          10.1038/343425a0
          1967820
          4bb1c66c-2c26-48a2-8dda-1c675f973e5a
          © 1990

          http://www.springer.com/tdm

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