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      Effect of occupational exposure to elemental mercury in the amalgam on thymulin hormone production among dental staff.

      1 , , ,
      Toxicology and industrial health
      SAGE Publications

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          Abstract

          Occupational exposure of dental staff to elemental mercury vapor released from dental amalgam is an issue of concern because of the possible immunological and neurological adverse outcomes. Recently, studies have reported that inorganic mercury induces immunosuppression by decreasing the production of thymus gland hormone (thymulin). This study aimed at investigating mercury body burden in dental staff and the relation of this burden to the potential impact of mercury on thymus gland hormone level (thymulin). Besides, the work aimed at verifying mercury effect on nitric oxide synthetase as a possible mechanism of its immunotoxicity. The study population consisted of a group of dental staff (n = 39) [21 dentists and 18 nurses] and a matched control group (n = 42). Each individual was subjected to detailed occupational and medical history taking and to estimation of urinary mercury (U-Hg) and blood mercury (B-Hg) as indicators of mercury body burden and exposure, respectively. Measurement of total thymulin hormone blood level, and plasma level of nitrite and nitrate (indicators of nitric oxide) was also done. The study showed a significantly increased U-Hg and B-Hg levels in the dental staff compared to their controls. This elevation of mercury body burden was associated with significant reduction in thymulin hormone blood level and nitric oxide parameters. These results were more evident in the group of nurses compared to the dentists. In conclusion, our results show that dentists and dental nurses have significant exposure to mercury vapor and point to the negative impact of mercury on thymus gland functions and confirm the implication that the nitric oxide pathway is a possible mechanism for this impact. Moreover, the study raises attention to the importance of hygiene measures in reduction of exposure to mercury vapor released from dental amalgam.

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          Author and article information

          Journal
          Toxicol Ind Health
          Toxicology and industrial health
          SAGE Publications
          0748-2337
          0748-2337
          Apr 2009
          : 25
          : 3
          Affiliations
          [1 ] Department of Occupational Diseases and Industrial Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.
          Article
          25/3/159
          10.1177/0748233709105270
          19482909
          4bb3aefb-e81f-4fed-b45b-8490baed692a
          History

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