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Abstract
The actions of prostacyclin (PGX) and several other derivatives of arachidonic acid
were examined on spiral-strips of bovine coronary artery. The strips were contracted
by PGE2 and thromboxane A2. Although PGH2 usually cause a transient contraction followed
by a relaxation, a few strips were only contracted whilst others were only relaxed.
Prostacyclin invariably relaxed coronary artery strips. Sodium arachidonate usually
relaxed the strips but occasionally had no effect. Indomethacin increased the resting
tone and abolished or substantially reduced the relaxation induced by sodium arachidonate.
15-hydroperoxy arachidonic acid (15-HPAA), a specific inhibitor of prostacyclin synthetase,
also increased the resting tone, abolished the effects of sodium arachidonate and
the relaxation component of the PGH2 response, but did not greatly modify the relaxation
induced by exogenous prostacyclin. These results strongly suggest that prostacyclin
mediates the relaxation induced by arachidonic acid in bovine coronary artery strips.
As PGH2 is avidly converted into prostacyclin by the vascular tissue of several species
including man, prostacyclin is probably involved in the local regulation of the coronary
vascular bed.