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Recombinant antibodies possessing novel effector functions.

Nature

Animals, Antibodies, Monoclonal, genetics, Antigen-Antibody Complex, Cell Line, Chimera, Cloning, Molecular, DNA Restriction Enzymes, Disulfides, Genes, Haptens, Hybridomas, immunology, Immunoglobulin Fab Fragments, Lymphocytes, Mice, Micrococcal Nuclease, metabolism, Oncogenes, Plasmacytoma, Transfection, Plasmids, Staphylococcus aureus, enzymology

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      Abstract

      The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.

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      6095112

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