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      Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest

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      Nature Genetics

      Springer Science and Business Media LLC

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          Abstract

          Mest (also known as Peg1), an imprinted gene expressed only from the paternal allele during development, was disrupted by gene targeting in embryonic stem (ES) cells. The targeted mutation is imprinted and reversibly silenced by passage through the female germ line. Paternal transmission activates the targeted allele and causes embryonic growth retardation associated with reduced postnatal survival rates in mutant progeny. More significantly, Mest-deficient females show abnormal maternal behaviour and impaired placentophagia, a distinctive mammalian behaviour. Our results provide evidence for the involvement of an imprinted gene in the control of adult behaviour.

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          Author and article information

          Journal
          Nature Genetics
          Nat Genet
          Springer Science and Business Media LLC
          1061-4036
          1546-1718
          October 1998
          October 1998
          : 20
          : 2
          : 163-169
          Article
          10.1038/2464
          9771709
          © 1998

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