Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Influence of Changes in Heart Rate, Aortic Pressure and Flow Rate upon Experimental Coronary Insufficiency

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This study was designed to evaluate the role of heart rate, aortic pressure, and aortic flow in the development of coronary insufficiency following acute coronary stenosis. In dogs, each of these parameters was controlled at a predetermined level while the left anterior descending coronary artery was constricted with a small screw clamp. The critical coronary pressure (CCP), i.e. the pressure below which a rise of left atrial pressure could be detected, was determined at various levels of hemodynamic load. Increases in aortic pressure, elevation of the heart rate and an increase in aortic flow rate were all associated with an elevation of the CCP and an increase in tension-time index (TTI). The changes in CCP were most striking when TTI was increased by aortic flow rate change. These findings suggest that with high aortic pressure, further constriction of coronary artery is required to precipitate coronary insufficiency, that the level of pacing required to induce coronary insufficiency is a useful index in assessing the degree of coronary stenosis, and that an augmentation of aortic flow rate is an important factor in the initiation of coronary insufficiency.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1974
          1974
          29 October 2008
          : 59
          : 4
          : 213-221
          Affiliations
          First Department of Internal Medicine, School of Medicine, University of Kanazawa, Kanazawa
          Article
          169684 Cardiology 1974;59:213–221
          10.1159/000169684
          4458944
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

          Comments

          Comment on this article