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      MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence

      review-article
      1 , 2 , 3 , , 4 , 1 , 5 , 4 , 4 , 6 , 1 , 7 , 8 , 9 , 1 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 31 , 32 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 48 , 49 , 50 , 51 , 52 , 53 , 50 , 51 , 54 , 55 , 56 , 57 , 56 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 67 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 3 , 88 , 89 , 90 , 91 , 91 , 92 , 93 , 94 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , MASK study group
      Clinical and Translational Allergy
      BioMed Central
      App, ARIA, Asthma, Care pathways, MASK, mHealth, Rhinitis

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          Abstract

          mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app ( the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.

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          Most cited references66

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          STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT

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              The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes.

              Lack of consensus on taxonomy, terminology, and definitions has led to confusion about which measurement properties are relevant and which concepts they represent. The aim was to clarify and standardize terminology and definitions of measurement properties by reaching consensus among a group of experts and to develop a taxonomy of measurement properties relevant for evaluating health instruments. An international Delphi study with four written rounds was performed. Participating experts had a background in epidemiology, statistics, psychology, and clinical medicine. The panel was asked to rate their (dis)agreement about proposals on a five-point scale. Consensus was considered to be reached when at least 67% of the panel agreed. Of 91 invited experts, 57 agreed to participate and 43 actually participated. Consensus was reached on positions of measurement properties in the taxonomy (68-84%), terminology (74-88%, except for structural validity [56%]), and definitions of measurement properties (68-88%). The panel extensively discussed the positions of internal consistency and responsiveness in the taxonomy, the terms "reliability" and "structural validity," and the definitions of internal consistency and reliability. Consensus on taxonomy, terminology, and definitions of measurement properties was reached. Hopefully, this will lead to a more uniform use of terms and definitions in the literature on measurement properties. Copyright 2010 Elsevier Inc. All rights reserved.
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                Author and article information

                Contributors
                +33 611 42 88 47 , jean.bousquet@orange.fr
                Journal
                Clin Transl Allergy
                Clin Transl Allergy
                Clinical and Translational Allergy
                BioMed Central (London )
                2045-7022
                25 October 2018
                25 October 2018
                2018
                : 8
                : 45
                Affiliations
                [1 ]MACVIA-France, Fondation Partenariale FMC VIA-LR, CHRU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, Montpellier, France
                [2 ]INSERM U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France
                [3 ]Euforea, Brussels, Belgium
                [4 ]KYomed-INNOV, Montpellier, France
                [5 ]iQ4U Consultants Ltd, London, UK
                [6 ]MedScript Ltd, Dundalk, Co Louth Ireland
                [7 ]ISNI 0000 0004 0369 268X, GRID grid.450308.a, Laboratoire HP2, Grenoble, INSERM, U1042, , Université Grenoble Alpes, ; Grenoble, France
                [8 ]ISNI 0000 0001 0792 4829, GRID grid.410529.b, CHU de Grenoble, ; Grenoble, France
                [9 ]Conseil Général de l’Economie Ministère de l’Economie, de l’Industrie et du Numérique, Paris, France
                [10 ]ISNI 0000 0001 1503 7226, GRID grid.5808.5, UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, , University of Porto (Porto4Ageing), ; Porto, Portugal
                [11 ]ISNI 0000 0001 1503 7226, GRID grid.5808.5, Center for Health Technology and Services Research- CINTESIS, Faculdade de Medicina, , Universidade do Porto, ; Porto, Portugal
                [12 ]Medida, Lda, Porto, Portugal
                [13 ]ISNI 0000 0001 2220 7094, GRID grid.7427.6, Faculty of Health Sciences and CICS – UBI, Health Sciences Research Centre, , University of Beira Interior, ; Covilhã, Portugal
                [14 ]Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
                [15 ]ISNI 0000 0000 9511 4342, GRID grid.8051.c, Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, , University of Coimbra, ; Coimbra, Portugal
                [16 ]ISNI 0000 0004 0372 8259, GRID grid.8399.b, ProAR – Nucleo de Excelencia em Asma, , Federal University of Bahia, ; Vitória da Conquista, Brazil
                [17 ]WHO GARD Planning Group, Salvador, Brazil
                [18 ]ISNI 0000 0001 2188 7235, GRID grid.411237.2, Allergy Service, , University Hospital of Federal University of Santa Catarina (HU-UFSC), ; Florianópolis, Brazil
                [19 ]ISNI 0000 0004 0411 4849, GRID grid.466704.7, Asthma Reference Center, , Escola Superior de Ciencias da Santa Casa de Misericordia de Vitoria, ; Vitória, Esperito Santo Brazil
                [20 ]Division for Health Innovation, Campania Region and Federico II University Hospital Naples (R&D and DISMET), Naples, Italy
                [21 ]ISNI 0000 0001 0790 385X, GRID grid.4691.a, CIRFF, , Federico II University, ; Naples, Italy
                [22 ]SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
                [23 ]ISNI 0000 0001 2336 6580, GRID grid.7605.4, Department of Medical Sciences, Allergy and Clinical Immunology Unit, , University of Torino & Mauriziano Hospital, ; Torino, Italy
                [24 ]Consortium of Pharmacies and Services COSAFER, Salerno, Italy
                [25 ]ISNI 0000 0001 0120 3326, GRID grid.7644.1, Unit of Geriatric Immunoallergology, , University of Bari Medical School, ; Bari, Italy
                [26 ]ISNI 0000 0004 1937 0335, GRID grid.11780.3f, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, , University of Salerno, ; Salerno, Italy
                [27 ]GRID grid.414741.3, Center of Excellence in Asthma and Allergy, , Hospital Médica Sur, ; México City, Mexico
                [28 ]Mexico City, Mexico
                [29 ]Puebla, Puebla Mexico
                [30 ]Ciutad Mexico, Mexico
                [31 ]ISNI 0000 0004 1937 1098, GRID grid.413776.0, Allergology Department, , Centre de l’Asthme et des Allergies Hôpital d’Enfants Armand-Trousseau (APHP), ; Paris, France
                [32 ]ISNI 0000 0001 2308 1657, GRID grid.462844.8, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, , Sorbonne Universités, ; Equipe EPAR, 75013 Paris, France
                [33 ]ISNI 0000 0001 2308 1657, GRID grid.462844.8, Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM, , UPMC Sorbonne Université, Medical School Saint Antoine, ; Paris, France
                [34 ]La Rochelle, France
                [35 ]ISNI 0000 0000 9961 060X, GRID grid.157868.5, Department of Respiratory Diseases, , Montpellier University Hospital, ; Montpellier, France
                [36 ]ISNI 0000 0004 4910 6535, GRID grid.460789.4, UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, , Université Paris-Saclay, ; Suresnes, France
                [37 ]Reims, France
                [38 ]ISNI 0000 0001 2165 3025, GRID grid.8267.b, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, , Medical University of Lodz, ; Lodz, Poland
                [39 ]ISNI 0000000113287408, GRID grid.13339.3b, Department of Prevention of Environmental Hazards and Allergology, , Medical University of Warsaw, ; Warsaw, Poland
                [40 ]ISNI 0000 0001 2243 2806, GRID grid.6441.7, Clinic of Children’s Diseases, and Institute of Health Sciences Department of Public Health, , Vilnius University Institute of Clinical Medicine, ; Vilnius, Lithuania
                [41 ]European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium
                [42 ]ISNI 0000 0001 2243 2806, GRID grid.6441.7, Clinic of Children’s Diseases, Faculty of Medicine, , Vilnius University, ; Vilnius, Lithuania
                [43 ]ISNI 0000 0001 2243 2806, GRID grid.6441.7, Faculty of Medicine, , Vilnius University, ; Vilnius, Lithuania
                [44 ]Woodbrook Medical Centre, Loughborough, UK
                [45 ]ISNI 0000 0004 1936 7988, GRID grid.4305.2, Allergy and Respiratory Research Group, Usher Institute of Population Health Sciences and Informatics, , University of Edinburgh, Medical School, ; Edinburgh, UK
                [46 ]ISNI 0000 0004 1936 7988, GRID grid.4305.2, Centre of Medical Informatics, Usher Institute of Population Health Sciences and Informatics, , The University of Edinburgh, ; Edinburgh, UK
                [47 ]ISNI 0000 0004 0478 9977, GRID grid.412004.3, Allergy Unit, Department of Dermatology, , University Hospital of Zurich, ; Zürich, Switzerland
                [48 ]Center for Rhinology and Allergology, Wiesbaden, Germany
                [49 ]ISNI 0000 0001 2190 4373, GRID grid.7700.0, Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, , Heidelberg University, ; Mannheim, Germany
                [50 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Comprehensive Allergy-Centre-Charité, Department of Dermatology and Allergy, , Charité - Universitätsmedizin Berlin, ; Berlin, Germany
                [51 ]Global Allergy and Asthma European Network (GA2LEN), Berlin, Germany
                [52 ]ISNI 0000 0000 8580 3777, GRID grid.6190.e, Institute of Medical Statistics, and Computational Biology, Medical Faculty, , University of Cologne, ; Cologne, Germany
                [53 ]CRI-Clinical Research International-Ltd, Hamburg, Germany
                [54 ]ISNI 0000 0000 8988 2476, GRID grid.11598.34, Department of Internal Medicine, , Medical University of Graz, ; Graz, Austria
                [55 ]ISNI 0000 0000 8988 2476, GRID grid.11598.34, Department of ENT, , Medical University of Graz, ; Graz, Austria
                [56 ]ISNI 0000000404654431, GRID grid.5650.6, Department of Otorhinolaryngology, , Academic Medical Centre, ; Amsterdam, The Netherlands
                [57 ]ISNI 0000000089452978, GRID grid.10419.3d, Department of Public Health and Primary Care, , Leiden University Medical Center, ; Leiden, The Netherlands
                [58 ]ISGlobAL, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
                [59 ]ISNI 0000 0004 1767 8811, GRID grid.411142.3, IMIM (Hospital del Mar Research Institute), ; Barcelona, Spain
                [60 ]ISNI 0000 0000 9314 1427, GRID grid.413448.e, CIBER Epidemiología y Salud Pública (CIBERESP), ; Barcelona, Spain
                [61 ]ISNI 0000 0001 2172 2676, GRID grid.5612.0, Universitat Pompeu Fabra (UPF), ; Barcelona, Spain
                [62 ]ISNI 0000 0001 0675 8654, GRID grid.411083.f, Allergy Section, Department of Internal Medicine, , Hospital Vall ‘dHebron & ARADyAL Research Network, ; Barcelona, Spain
                [63 ]ISNI 0000 0001 0671 0327, GRID grid.413521.0, AQuAS, ; Barcelona, Spain
                [64 ]EUREGHA, European Regional and Local Health Association, Brussels, Belgium
                [65 ]ISNI 0000 0004 1937 0247, GRID grid.5841.8, Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic, , University of Barcelona, ; Barcelona, Spain
                [66 ]ISNI 0000 0004 1937 0247, GRID grid.5841.8, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, , University of Barcelona, ; Barcelona, Spain
                [67 ]ISNI 0000 0000 9950 5666, GRID grid.15485.3d, Skin and Allergy Hospital, , Helsinki University Hospital, ; Helsinki, Finland
                [68 ]Association of Finnish Pharmacists, Helsinki, Finland
                [69 ]ISNI 0000 0001 2097 1371, GRID grid.1374.1, Department of Lung Diseases and Clinical Immunology, , University of Turku, ; Turku, Finland
                [70 ]Terveystalo Allergy Clinic, Turku, Finland
                [71 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, , Istanbul University, ; Istanbul, Turkey
                [72 ]ISNI 0000 0004 0595 6052, GRID grid.411688.2, Department of Pulmonary Diseases, Faculty of Medicine, , Celal Bayar University, ; Manisa, Turkey
                [73 ]GARD Executive Committee, Manisa, Turkey
                [74 ]ISNI 0000000121662407, GRID grid.5379.8, Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children’s Hospital, , University of Manchester, ; Manchester, UK
                [75 ]ISNI 0000 0001 2155 0800, GRID grid.5216.0, Allergy Department, 2nd Pediatric Clinic, Athens General Children’s Hospital “P&A Kyriakou”, , University of Athens, ; 11527 Athens, Greece
                [76 ]ISNI 0000 0004 0576 3437, GRID grid.8127.c, Department of Otorhinolaryngology, , University of Crete School of Medicine, ; Heraklion, Greece
                [77 ]Woolcock Institute of Medical Research, University of Sydney and Sydney Local Health District, Glebe, NSW Australia
                [78 ]ISNI 0000 0004 1936 7857, GRID grid.1002.3, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, , Monash University, ; Melbourne, VIC Australia
                [79 ]ISNI 0000 0004 1936 7857, GRID grid.1002.3, Department of Immunology, , Monash University, ; Melbourne, VIC Australia
                [80 ]Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
                [81 ]Director of Center of Allergy, Immunology and Respiratory Diseases, Santa Fe, Argentina Center for Allergy and Immunology, Santa Fe, Argentina
                [82 ]ISNI 0000 0000 9878 4966, GRID grid.411954.c, Universidad Católica de Córdoba, ; Córdoba, Argentina
                [83 ]ISNI 0000 0000 8986 2221, GRID grid.416648.9, Department of Clinical Science and Education, Karolinska Institutet, , Södersjukhuset, ; Stockholm, Sweden
                [84 ]ISNI 0000 0000 8986 2221, GRID grid.416648.9, Sachs’ Children and Youth Hospital, , Södersjukhuset, ; Stockholm, Sweden
                [85 ]ISNI 0000 0004 1937 0626, GRID grid.4714.6, Institute of Environmental Medicine, , Karolinska Institutet, ; Stockholm, Sweden
                [86 ]ISNI 0000 0004 1936 9457, GRID grid.8993.b, Centre for Clinical Research Sörmland, , Uppsala University, ; Eskilstuna, Sweden
                [87 ]ISNI 0000 0004 0626 3303, GRID grid.410566.0, Upper Airways Research Laboratory, ENT Department, , Ghent University Hospital, ; Ghent, Belgium
                [88 ]ISNI 0000 0004 0626 3338, GRID grid.410569.f, Department of Otorhinolaryngology, , Univ Hospitals Leuven, ; Louvain, Belgium
                [89 ]ISNI 0000000084992262, GRID grid.7177.6, Academic Medical Center, , University of Amsterdam, ; Amsterdam, The Netherlands
                [90 ]GRID grid.434606.3, EFA European Federation of Allergy and Airways Diseases Patients’ Associations, ; Brussels, Belgium
                [91 ]Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark
                [92 ]ISNI 0000 0004 1936 8227, GRID grid.25073.33, Department of Medicine, Clinical Immunology and Allergy, , McMaster University, ; Hamilton, ON Canada
                [93 ]ISNI 0000 0004 0609 2225, GRID grid.412730.3, University Hospital Olomouc, ; Olomouc, Czech Republic
                [94 ]Peercode BV, Geldermalsen, The Netherlands
                [95 ]ISNI 0000 0001 2159 8361, GRID grid.5120.6, Faculty of Medicine, , Transylvania University, ; Brasov, Romania
                [96 ]ISNI 0000 0001 2353 285X, GRID grid.170693.a, Division of Allergy/Immunology, , University of South Florida, ; Tampa, USA
                [97 ]ISNI 0000 0004 1936 9342, GRID grid.262962.b, Section of Allergy and Immunology, , Saint Louis University School of Medicine, ; Saint Louis, MO USA
                [98 ]ISNI 0000 0001 2171 9311, GRID grid.21107.35, Johns Hopkins School of Medicine, ; Baltimore, MD USA
                [99 ]ISNI 0000 0004 0632 2959, GRID grid.411321.4, Department of Otorhinolaryngology, , Chiba University Hospital, ; Chiba, Japan
                [100 ]ISNI 0000 0001 2168 8324, GRID grid.261241.2, Nova Southeastern University, ; Fort Lauderdale, Florida USA
                Article
                227
                10.1186/s13601-018-0227-6
                6201545
                30534360
                4bd1c25c-f6b3-4255-aaa6-24e958c66c56
                © The Author(s) 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 31 July 2018
                : 7 September 2018
                Categories
                Review
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                © The Author(s) 2018

                Immunology
                app,aria,asthma,care pathways,mask,mhealth,rhinitis
                Immunology
                app, aria, asthma, care pathways, mask, mhealth, rhinitis

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