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      Pruritus and Hydration State of Stratum corneum in Hemodialysis Patients

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          Abstract

          Background: Xerosis is the most frequent cutaneous manifestation in hemodialysis (HD) patients, but the association between dry skin and pruritus remains to be clarified. Since the skin surface hygrometer can detect the changes of water content in the stratum corneum more sensitively, we re-examined the relationship between the severity of pruritus and water content in dialysis patients. Methods: Fifty patients who had been undergoing regular HD were examined for the degree of pruritus by clinical grading. Water contents in the stratum corneum at volar forearm and lower leg were assessed by measurement of high-frequency conductance using a skin surface hygrometer both at pre- and postdialysis. Results: Thirty-seven (74%) of dialysis patients complained of pruritus. High-frequency conductance values were significantly lower in HD patients compared to those of age-matched control subjects (n = 13) both at forearm (35.1 ± 3.0 vs. 73.3 ± 10.4 µS, p < 0.01) and lower leg (14.2 ± 1.1 vs. 52.4 ± 7.5 µS, p < 0.01). There was no relationship between the severity of pruritus and age, gender, HD duration, underlying renal disease, or removing fluid volume. A significant reduction of itching score was found in patients using polysulfone membrane. A single HD session using cellulose triacetate or polysulfone membrane significantly increased water content both at forearm and lower leg (p < 0.05). However, the degree of pruritus did not correlate with the skin water content both at the beginning and the end of HD session, respectively. Conclusion: It follows from these findings that water content in the stratum corneum was reduced in HD patients, but did not correlate with the severity of pruritus.

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          Author and article information

          Journal
          AJN
          Am J Nephrol
          10.1159/issn.0250-8095
          American Journal of Nephrology
          S. Karger AG
          0250-8095
          1421-9670
          2000
          December 2000
          22 December 2000
          : 20
          : 6
          : 437-442
          Affiliations
          aFirst Department of Medicine, Hamamatsu University School of Medicine and bMaruyama Clinic, Hamamatsu, Japan
          Article
          46196 Am J Nephrol 2000;20:437–442
          10.1159/000046196
          11146309
          © 2000 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 2, Tables: 2, References: 24, Pages: 6
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/46196
          Categories
          Clinical Study

          Cardiovascular Medicine, Nephrology

          Skin surface hygrometer, Pruritus, Xerosis, Hemodialysis

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